Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. - sprookjes - yvandenbroek - TriplyDB

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

http://www.wikidata.org/entity/Q39705049

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HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1 Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development Molecular basis of cleft palates in mice Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice Effects of histone deacetylase inhibitors on HIF-1 Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish Systematic identification of gene activities promoting hypoxic death.Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus.FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells.Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control Mitophagy and cancer.The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy.Hypoxia-induced and stress-specific changes in chromatin structure and function.Is histone acetylation the most important physiological function for CBP and p300?Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.Hypoxia induces a novel signature of chromatin modifications and global repression of transcription.Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions The TIP60 Complex Is a Conserved Coactivator of HIF1A The genomic landscape of hypodiploid acute lymphoblastic leukemia.Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

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Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

http://www.wikidata.org/entity/Q39705049

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Two transactivation mechanisms ...... -1-responsive gene expression.

@en

Two transactivation mechanisms ...... -1-responsive gene expression.

@nl

type

label

Two transactivation mechanisms ...... -1-responsive gene expression.

@en

Two transactivation mechanisms ...... -1-responsive gene expression.

@nl

prefLabel

Two transactivation mechanisms ...... -1-responsive gene expression.

@en

Two transactivation mechanisms ...... -1-responsive gene expression.

@nl

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SJ.EMBOJ.7600846

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The EMBO Journal

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Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression

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P2093

Jerold Rehg

http://www.w3.org/2001/XMLSchema#string

John L Cleveland

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Kelli Boyd

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Lawryn H Kasper

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Michelle Biesen

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Troy A Baudino

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Wu Xu

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P2860

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.

Targeting HIF-1 for cancer therapy

CBP/p300 in cell growth, transformation, and development

Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung

CBP histone acetyltransferase activity is a critical component of memory consolidation

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10.1038/SJ.EMBOJ.7600846

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22

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24

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Fayçal Boussouar

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2005-10-20T00:00:00Z

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7529961

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16237459

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1283945

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