Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. - sprookjes - yvandenbroek - TriplyDB

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

http://www.wikidata.org/entity/Q39989774

about

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists Therapeutic considerations for Mdm2: not just a one trick pony trans-rac-[1-Oxo-2-phenethyl-3-(2-thien-yl)-1,2,3,4-tetra-hydro-isoquinolin-4-yl]methyl 4-methyl-benzene-sulfonate Methyl trans-(±)-1-oxo-2-phenethyl-3-(thio-phen-2-yl)-1,2,3,4-tetra-hydro-isoquinoline-4-carboxyl-ate Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor Chemistry and biology of multicomponent reactions.The MDM2-p53 pathway revisited Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?The p53-MDM2/MDMX axis - A chemotype perspective.Patented inhibitors of p53-Mdm2 interaction (2006 - 2008).NMR-based screening of membrane protein ligands.Inhibitors of MDM2 and MDMX: a structural perspective.Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Prospective virtual screening for novel p53-MDM2 inhibitors using ultrafast shape recognition.Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels.Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline.Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids.

P2860

Q28481449-AA762B6A-207A-4BA6-935A-AAE39829745E Q30380490-2884641E-181E-4F49-ACEA-EAC101C615EB Q34223458-AAEABD94-7B5F-4579-BD0A-754592AA07C7 Q34265336-F8A30A36-A718-431E-9E75-E32938415D6F Q35011473-79A7EC53-DCFD-48F4-BBCF-BBA908C8DEC2 Q35199094-5798A6AF-8984-4E77-BE8B-E697EF503486 Q37017587-EFD769C9-822E-4B78-A5B1-1D735E1BEC29 Q37039474-DA550BFA-B716-4F09-BCFD-C6153E6F28DE Q37068706-8239143E-5B06-489F-BF08-5E3C90E8443D Q37503463-C3FFE8A8-E994-42FD-B8CC-2C460EBBE618 Q37680961-BF8857E9-AE52-4943-A452-03D2E060059A Q37717767-F47F16F9-B065-41C3-B518-E9CD7BF6D09F Q37855826-78BFEEA6-DDD2-49B5-8998-C52377E5E6FB Q38865504-3E5C35CC-4B51-444D-A4F5-B3F24A9EA72B Q39022371-1C297FE9-119A-4042-9979-080C62E71B49 Q39288532-0220671B-3261-4DA6-9E3D-58DA70326EF7 Q39606430-AEDE7A80-A023-42A6-9E18-ABF6AE00DD51 Q41147670-50931A55-8773-43BB-B6E5-4BD44BC1ABF1 Q53172454-F5B17576-88BE-4429-AF39-37585BC2158E Q53272138-AD38A407-B6F1-4E55-8F42-D6026A59620A

P2860

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

http://www.wikidata.org/entity/Q39989774

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@en

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@nl

type

label

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@en

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@nl

prefLabel

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@en

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@nl

P1433

Q39989774-18C9E98B-8CBF-4494-8C12-141F845F7876

P1476

Q39989774-E32C1F7D-1DA1-41C2-8A8E-9BADA388742B

P2093

Q39989774-01C4A625-60C5-49EE-86B5-1CA68E285D2E

Q39989774-3CE4D699-0F06-452C-93A2-1238AB57031B

Q39989774-4F992B9B-F7E6-4B44-9E1C-E8AC0FA0F294

Q39989774-5BFDF7E1-26B0-47E1-A268-342C0D460F7C

Q39989774-877B05DB-6D5F-45E8-AFAE-568F0BD841D5

Q39989774-AA07F101-E27C-4C0E-9208-A26E1B22C31D

Q39989774-B2984650-B117-4779-A87F-95815F0E1671

Q39989774-CA163F58-F184-49A4-911A-DC38A84F6D7E

Q39989774-D92024DB-37F5-4A27-AF86-F95F4D791380

Q39989774-E9592D1F-9474-4190-8E4B-2EB16CBF7EAE

P2860

Q39989774-06D2C0C6-5F69-4A10-9416-296358BF53DD

Q39989774-97562299-E29E-4453-BEA9-EB98CD32B337

P304

Q39989774-A9BA7C5A-DC62-414A-83B9-610A4CCB8F09

P31

Q39989774-4A00E012-EF1B-4550-910A-B89F31B93C7B

P356

Q39989774-A0304040-AB01-4F34-A48D-F7BBFCC594B8

P433

Q39989774-CE958945-01D1-4CB1-B601-4D5B078678F9

P478

Q39989774-7CA17D64-5D8E-48BD-BE70-338796FBCDBA

P577

Q39989774-6E43442A-D72B-4AAB-91BD-49F751ABF26D

P698

Q39989774-ABE4050C-407C-4FBB-B43B-C5665F8B0F80

P356

P1433

P1476

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.

@en

P2093

Anna Czarna

http://www.w3.org/2001/XMLSchema#string

Cédric Kalinski

http://www.w3.org/2001/XMLSchema#string

Günther Ross

http://www.w3.org/2001/XMLSchema#string

Jolanta Ciombor

http://www.w3.org/2001/XMLSchema#string

Lutz Weber

http://www.w3.org/2001/XMLSchema#string

Marcin Krajewski

http://www.w3.org/2001/XMLSchema#string

Natalia Skobeleva

http://www.w3.org/2001/XMLSchema#string

Tad A Holak

http://www.w3.org/2001/XMLSchema#string

Ulli Rothweiler

http://www.w3.org/2001/XMLSchema#string

Vladimir Khazak

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular basis for the inhibition of p53 by Mdmx

Mapping of the p53 and mdm-2 interaction domains

P304

1118-1128

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/CMDC.200800025

http://www.w3.org/2001/XMLSchema#string

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2008-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18428185

http://www.w3.org/2001/XMLSchema#string