The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.
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Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithmActin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilliChallenges of using in vitro data for modeling P-glycoprotein efflux in the blood-brain barrier.Extraction of elementary rate constants from global network analysis of E. coli central metabolism.The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transportersModulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos.A mathematical feasibility argument for the use of aptamers in chemotherapy and imaging.Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levelsStrategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling.Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions.In vitro methods to support transporter evaluation in drug discovery and development.Calcein assay: a high-throughput method to assess P-gp inhibition.Assessment and modulation of phillyrin absorption by P-gp using Caco-2 cells and MDR1-MDCKII cells.Role of the plasma membrane leaflets in drug uptake and multidrug resistance.Cells on pores: a simulation-driven analysis of transcellular small molecule transport.Prosecretory effect of loperamide in ileal and colonic mucosae of mice displaying high or low swim stress-induced analgesia associated with high and low endogenous opioid system activity.Kinetic modelling of passive transport and active efflux of a fluoroquinolone across Caco-2 cells using a compartmental approach in NONMEM.Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane.The importance of villous physiology and morphology in mechanistic physiologically-based pharmacokinetic models.Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition.Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.
P2860
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P2860
The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The elementary mass action rat ...... nolayer of MDCKII-hMDR1 cells.
@en
type
label
The elementary mass action rat ...... nolayer of MDCKII-hMDR1 cells.
@en
prefLabel
The elementary mass action rat ...... nolayer of MDCKII-hMDR1 cells.
@en
P2093
P2860
P1433
P1476
The elementary mass action rat ...... onolayer of MDCKII-hMDR1 cells
@en
P2093
Andrew Ayrton
Harma Ellens
Tanya Aldinger
Thuy Thanh Tran
P2860
P304
P356
10.1529/BIOPHYSJ.104.045633
P407
P577
2004-10-22T00:00:00Z