Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion.
about
Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowthA molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein responseOlfactomedin proteins: central players in development and diseaseOverexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma.Unraveling the pathophysiology of Sjogren syndrome-associated dry eye diseaseMatricellular proteins in the trabecular meshwork: review and update.Functional role of proteolytic processing of recombinant myocilin in self-aggregationRescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones.Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor.Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Effects of transforming growth factor-β2 on myocilin expression and secretion in human primary cultured trabecular meshwork cellsEstablishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell linesThe stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.Structural basis for misfolding in myocilin-associated glaucoma.Molecular chaperone function for myocilinClinical features associated with an Asp380His Myocilin mutation in a US family with primary open-angle glaucoma.Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cellsOptimized bacterial expression of myocilin proteins and functional comparison of bacterial and eukaryotic myocilins.FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25.Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.Myocilin variations and familial glaucoma in Taxiarchis, a small Greek villageTwo novel myocilin mutations in a Chinese family with primary open-angle glaucoma.A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor.Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy.Glaucoma-associated myocilin: a better understanding but much more to learn.The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway.The novel Y371D myocilin mutation causes an aggressive form of juvenile open-angle glaucoma in a Caucasian family from the Middle-EastA Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Targeting the ER-autophagy system in the trabecular meshwork to treat glaucomaDiscovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.Roles of exosomes in the normal and diseased eye.Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.Dexamethasone increases Cdc42 expression in human TM-1 cells.Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma.RNA interference as a gene silencing therapy for mutant MYOC protein in primary open angle glaucoma.
P2860
Q24329037-69F71827-4EFF-4D01-AFAC-E25F6B3C6D40Q26828355-BCB0F7E1-5971-46E7-901B-7AC88E4FAF20Q26851669-C3F023F9-A97B-4B1E-975F-E202E71C438FQ33400356-798E19C2-E212-4B5A-BEFE-A1E68EB9D730Q33808845-F502648C-5BDE-4828-A083-AC35D0D123C2Q33819490-9CF7A5C0-D9B4-4DB3-ADCF-F8830B403961Q33820048-979DFDB2-3919-4F85-B60A-A949CFF75851Q33847413-43989707-0664-44E7-A4D8-74738730A696Q33869299-4462AFBC-91EC-4312-9A5A-657950EFEE3FQ33938138-81280E6A-ADB9-4E7B-A7AE-4DFBD456B73EQ34116120-3561CEC0-96AA-4039-A27C-698129453391Q34121388-C5350683-6391-4C71-9A0A-5205A7F5DC1FQ34452059-B1AD6D63-E013-4ED4-B93F-A3CBA21FFAB7Q35083487-A8BA32D4-9DC6-430B-9AD8-94825DFE8DF0Q35131549-A4E01FB0-FDD2-40EE-973D-0BC7C2E041ECQ35234066-090D3D11-5AFC-4810-9F8F-2FA598237C98Q35247676-B373B8B0-DAA4-4957-9339-3B21CCB3864DQ35940374-0AFE291C-8483-4150-8865-3BF657C4E089Q36075362-D063EBE8-AABE-4A48-B7FE-22251556C009Q36143392-F332F73B-B686-4FDB-BEC7-128F331BED8FQ36390833-459B4BC6-12AD-45F8-962B-6A2250907940Q36418920-1DC18EDF-93C7-4A16-9F9E-AA06256DAC9EQ36606709-166CF917-877E-4FC9-A8AF-869D2696828BQ36864324-238B21DA-2B7F-4532-AE6C-8FE3B0B1C070Q36901991-335B27D7-DB84-4DA2-B3B0-0C050D7D1E97Q36978194-D773D09C-500D-40AF-888D-DBB80478CBEAQ37129577-45845C35-31E5-4848-863E-78602AA5BA4BQ37193799-86A97733-C9B9-460E-9B76-01783198738FQ37294759-F0155A76-D0CD-4AED-B0C4-5F2AC4308DFAQ37362502-A1A1A2A2-0329-4EF5-A139-31B47D84573FQ37415633-511E43A7-39A2-4A53-AFFF-D80A218FFADCQ37710660-ECD6D7E3-30AB-47F3-B53A-6404EC042A8CQ38572659-57FF1D9E-72B5-4334-932B-A41EC13103F7Q38584194-D45ADE91-A2C8-4706-97C2-AF878BC9B88BQ38688358-C40BF732-B7BE-4463-B80C-664D6598088FQ38703911-42999D36-C15D-458B-893F-234A2309A30AQ38990708-F159ADD2-4F63-4208-B44F-709D1BD23A22Q40103210-8F802514-3034-4E49-9A28-406040E31A18Q42111387-288A9850-33A0-4C95-8D0D-E80EE5BB62D9Q42714252-C5EECE64-3657-46EF-A519-1027B41AD943
P2860
Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Functional analysis of the gla ...... llular adhesion and secretion.
@en
type
label
Functional analysis of the gla ...... llular adhesion and secretion.
@en
prefLabel
Functional analysis of the gla ...... llular adhesion and secretion.
@en
P2093
P1476
Functional analysis of the gla ...... llular adhesion and secretion.
@en
P2093
Laurence Letartre
Stéphane Gobeil
Vincent Raymond
P304
P356
10.1016/J.EXER.2005.11.002
P577
2006-02-08T00:00:00Z