gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
about
Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.Pathological and physiological functions of presenilins.First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanismsThe role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidAZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
P2860
Q33327152-65A8B18B-E714-4E11-926D-8CDB2C7B6278Q33726342-0F2152B2-9D6D-461D-B497-D420DA40EF5EQ34803524-36906EE3-8112-489D-9F4A-C215235ACDA1Q35874372-952EBF24-E619-4BE5-967B-EF1E04525235Q36582358-E8B548BD-4F73-442C-BB17-D235686F5384Q37053876-CDA65871-F52E-4284-BBFE-66E3FE581EE6Q38737484-66B35089-0795-412F-8074-B080988F83ACQ42118696-0569DE5F-4E84-45B6-8555-C9CDC7D2D106
P2860
gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
gamma-Secretase complexes cont ...... rmal gamma-secretase activity.
@en
type
label
gamma-Secretase complexes cont ...... rmal gamma-secretase activity.
@en
prefLabel
gamma-Secretase complexes cont ...... rmal gamma-secretase activity.
@en
P2093
P2860
P1476
gamma-Secretase complexes cont ...... rmal gamma-secretase activity.
@en
P2093
Emil M Hansson
Hanna Laudon
Jan Näslund
Johan Lundkvist
Kia Strömberg
Susanne Bergstedt
P2860
P304
P356
10.1111/J.1471-4159.2005.03415.X
P407
P577
2005-08-31T00:00:00Z