SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.
about
The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activationThe adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling.SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.The adaptor protein SAP regulates type II NKT-cell development, cytokine production, and cytotoxicity against lymphoma.
P2860
SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.
description
2003 nî lūn-bûn
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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name
SLAM-associated protein defici ...... roliferative disease patients.
@en
type
label
SLAM-associated protein defici ...... roliferative disease patients.
@en
prefLabel
SLAM-associated protein defici ...... roliferative disease patients.
@en
P2093
P2860
P356
P1476
SLAM-associated protein defici ...... roliferative disease patients.
@en
P2093
Fabio Candotti
Gerhard Fritsch
Maddalena Soncini
Marcus D Saemann
Maximilian Zeyda
Ornella Parolini
Silvia Sanzone
Thomas M Stulnig
Walter Knapp
Wolfgang Holter
P2860
P304
29593-29599
P356
10.1074/JBC.M300565200
P407
P577
2003-05-23T00:00:00Z