PDGF alpha- and beta-receptors activate unique and common signal transduction pathways. - sprookjes - yvandenbroek - TriplyDB

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

http://www.wikidata.org/entity/Q41516226

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Rho GTPases have diverse effects on the organization of the actin filament system PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.Structural and functional studies on platelet-derived growth factor Structural and functional properties of platelet-derived growth factor and stem cell factor receptors WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase.Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells Tissue plasminogen activator is a potent activator of PDGF-CC Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres.Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans.Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling.Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy.Regulation of macropinocytosis by p21-activated kinase-1 The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors PDGFRα and β play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance.Prognostic value of platelet derived growth factor alpha receptor expression in grade 2 astrocytomas and oligoastrocytomas.Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors.Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells Association of platelet-derived growth factor receptor alpha mutations with gastric primary site and epithelioid or mixed cell morphology in gastrointestinal stromal tumors.Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.In vivo tracking of mesechymal stem cells using fluorescent nanoparticles in an osteochondral repair model.Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors.Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.Mechanistic insights into the regulation of circular dorsal ruffle formation.Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays.Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor.Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging De novo generation of permanent neovascularized soft tissue appendages by platelet-derived growth factor.Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study.Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

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P2860

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

http://www.wikidata.org/entity/Q41516226

description

1992 nî lūn-bûn

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1992年の論文

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1992年論文

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1992年論文

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1992年論文

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1992年論文

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1992年論文

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1992年论文

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1992年论文

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1992年论文

@zh-cn

name

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

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type

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PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

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prefLabel

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

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J.1460-2075.1992.TB05085.X

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The EMBO Journal

P1476

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways

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P2093

Claesson-Welsh L

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Eriksson A

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Heldin CH

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Siegbahn A

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P2860

Binding of GAP to activated PDGF receptors

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

Two different subunits associate to create isoform-specific platelet-derived growth factor receptors

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

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543-550

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10.1002/J.1460-2075.1992.TB05085.X

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2

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11

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Bengt Westermark

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1992-02-01T00:00:00Z

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1311251

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556485

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