about
A renaissance in trace amines inspired by a novel GPCR familyTrace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptorsTrace amine associated receptor 1 signaling in activated lymphocytesTAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activityThe selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic systemTAAR1 Modulates Cortical Glutamate NMDA Receptor Function.The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA ("ecstasy") in humansPhosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteinsTrace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromersDuloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory studySimilar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings.Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773).Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seekingA functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans.Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.Monoamine transporter and receptor interaction profiles of a new series of designer cathinones.Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones.Pharmacological profile of novel psychoactive benzofurans.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 AgonistsBrain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamineThe impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis.Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges.Geldanamycin restores a defective heat shock response in vivo.Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds.The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects.Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampusPartial cortical devascularization results in elevations of cortical nerve growth factor and increases nerve growth factor protein within basal forebrain cholinergic neurons.Interaction Between the Trace Amine-Associated Receptor 1 and the Dopamine D2 Receptor Controls Cocaine's Neurochemical ActionsEffects of the α₂-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers.The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null mice.TAAR1-dependent effects of apomorphine in mice.Reversible sedimentation and masking of nerve growth factor (NGF) antigen by high molecular weight fractions from rat brain.Nerve growth factor (NGF) content in adult rat brain tissues is several-fold higher than generally reported and is largely associated with sedimentable fractions.A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marius Hoener
@ast
Marius Hoener
@en
Marius Hoener
@es
Marius Hoener
@nl
Marius Hoener
@sl
type
label
Marius Hoener
@ast
Marius Hoener
@en
Marius Hoener
@es
Marius Hoener
@nl
Marius Hoener
@sl
altLabel
M C Hoener
@en
Marius C. Hoener
@en
prefLabel
Marius Hoener
@ast
Marius Hoener
@en
Marius Hoener
@es
Marius Hoener
@nl
Marius Hoener
@sl
P1053
I-6464-2012
P106
P21
P2798
P31
P3829
P496
0000-0001-6510-6250