Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
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Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive LeukemiasThe PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapyTargeting the phosphoinositide 3-kinase pathway in hematologic malignanciesAdult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesAnticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers.Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice.Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1).Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia.p110δ PI3 kinase pathway: emerging roles in cancer.Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.The phosphatidylinositol-3 kinase I inhibitor BKM120 induces cell death in B-chronic lymphocytic leukemia cells in vitro.STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-cateninEmetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets.Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches.Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways.Apoptosis inducers in chronic lymphocytic leukemia.Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor.CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia.Targeting CK2-driven non-oncogene addiction in B-cell tumors.Personalized Drug Analysis in B Cell Chronic Lymphocytic Leukemia Patients.Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.Constitutive Phosphorylation of STAT3 by the CK2-BLNK-CD5 Complex.Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic lymphocytic leukaemia (CLL) cells.Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones.Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemiaPrecision spherical nucleic acids for delivery of anticancer drugs.Reactivating nuclear PTEN to treat CLL.Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia.
P2860
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P2860
Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@en
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@nl
type
label
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@en
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@nl
prefLabel
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@en
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@nl
P2093
P1433
P1476
Reconstitution of PTEN activit ...... chronic lymphocytic leukemia.
@en
P2093
Alexander Gaiger
Andrea Hoelbl
Christoph Zielinski
Claudia Lehner
Dita Demirtas
Elena Ponath
Josef D Schwarzmeier
Markus Duechler
Martin Hilgarth
Medhat Shehata
P304
P356
10.1182/BLOOD-2009-10-248054
P407
P577
2010-06-24T00:00:00Z