Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.
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Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphineCurcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitorInterpatient variability in dexmedetomidine response: a survey of the literatureInterindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system.Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liverRenal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetablesUDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP.PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.The microbial pharmacists within us: a metagenomic view of xenobiotic metabolismChemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.Regulation of hepatic phase II metabolism in pregnant miceA multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk.Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteersAltered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.UGT concentrations in human rectal tissue after multidose, oral curcuminAcetaminophen dose does not predict outcome in acetaminophen-induced acute liver failureThe UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers.Can paracetamol (acetaminophen) be administered to patients with liver impairment?Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates.Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats.Comparison of 2,2-bis(bromomethyl)-1,3-propanediol induced genotoxicity in UROtsa cells and primary rat hepatocytes: relevance of metabolism and oxidative stressApplication of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in childrenSex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p.UGT2B gene expression analysis in multiple tobacco carcinogen-targeted tissues.Pharmacogenomics of acetaminophen in pediatric populations: a moving target.Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes.Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model.Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro.
P2860
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P2860
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Interindividual variability in ...... curonosyltransferase isoforms.
@en
Interindividual variability in ...... curonosyltransferase isoforms.
@nl
type
label
Interindividual variability in ...... curonosyltransferase isoforms.
@en
Interindividual variability in ...... curonosyltransferase isoforms.
@nl
prefLabel
Interindividual variability in ...... curonosyltransferase isoforms.
@en
Interindividual variability in ...... curonosyltransferase isoforms.
@nl
P2093
P1476
Interindividual variability in ...... ucuronosyltransferase isoforms
@en
P2093
C J Patten
D J Greenblatt
J O Miners
L L von Moltke
P I Mackenzie
P304
P407
P577
2001-12-01T00:00:00Z