Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).
about
A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsDifferent roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channelsThe Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channelTrafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutationThe subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domainsDistal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channelsAbsence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methodsInteraction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncopeRole of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.hERG potassium channel gating is mediated by N- and C-terminal region interactionsCytoplasmic domains and voltage-dependent potassium channel gating.Insights into hERG K+ channel structure and function from NMR studies.Voltage-dependent gating of HERG potassium channels.Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells.An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix.Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region.KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents.Express with caution: Epitope tags and cDNA variants effects on hERG channel trafficking, half-life and function.Length-dependent regulation of the Kv1.2 channel activation by its C-terminus.Extracellular potassium effects are conserved within the rat erg K+ channel family.Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.BEHAVIORAL GENETICS OFCAENORHABDITIS ELEGANS UNC-103-ENCODED ERG-LIKE K+CHANNEL
P2860
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P2860
Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Functional characterization of the C-terminus of the human ether-à-go-go-related gene K
@nl
Functional characterization of ...... ated gene K(+) channel (HERG).
@en
type
label
Functional characterization of the C-terminus of the human ether-à-go-go-related gene K
@nl
Functional characterization of ...... ated gene K(+) channel (HERG).
@en
prefLabel
Functional characterization of the C-terminus of the human ether-à-go-go-related gene K
@nl
Functional characterization of ...... ated gene K(+) channel (HERG).
@en
P2860
P1476
Functional characterization of ...... ated gene K(+) channel (HERG).
@en
P2093
P2860
P356
10.1111/J.1469-7793.2001.T01-3-00001.X
P407
P577
2001-07-01T00:00:00Z