Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
about
Transgenic rodent models of Parkinson’s diseaseSynphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synucleinA product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathParkin ubiquitinates and promotes the degradation of RanBP2Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Parkin mono-ubiquitinates Bcl-2 and regulates autophagyStaring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradationSynaptic vesicle trafficking and Parkinson's diseaseParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationParkin accumulation in aggresomes due to proteasome impairmentParkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagyParkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationParkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell deathSynphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patientsAtaxin-3 is a multivalent ligand for the parkin Ubl domainHow does parkin ligate ubiquitin to Parkinson's disease?Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowthThe synucleinsGenetics of Parkinson diseaseNUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channelsDopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosisParkin counteracts symptoms in a Drosophila model of Parkinson's disease.Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)Parkin Regulation and Neurodegenerative DisordersRBR E3 ubiquitin ligases: new structures, new insights, new questionsParkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth.Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domainStructure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease14-3-3eta is a novel regulator of parkin ubiquitin ligase.The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesCasein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formationAssociation of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathiesTriad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptorsAggresome formation and neurodegenerative diseases: therapeutic implicationsSubgroup-specific structural variation across 1,000 medulloblastoma genomes
P2860
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P2860
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@ast
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en-gb
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@nl
type
label
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@ast
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en-gb
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@nl
prefLabel
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@ast
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en-gb
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@nl
P2093
P921
P3181
P356
P1433
P1476
Parkin ubiquitinates the alpha ...... formation in Parkinson disease
@en
P2093
T M Dawson
V L Dawson
P2888
P304
P3181
P356
10.1038/NM1001-1144
P407
P577
2001-10-01T00:00:00Z
P5875
P6179
1036299922