14-3-3eta is a novel regulator of parkin ubiquitin ligase.
about
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicityFbxo45, a novel ubiquitin ligase, regulates synaptic activity14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationParkin Regulation and Neurodegenerative DisordersRBR E3 ubiquitin ligases: new structures, new insights, new questions14-3-3 protein targets misfolded chaperone-associated proteins to aggresomesDEGAS: de novo discovery of dysregulated pathways in human diseasesParkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain14-3-3theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor BaxParkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTSSu(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologueBiochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.Protein-protein interactions as drug targets.14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease.MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination.The ring between ring fingers (RBR) protein familyProgress in the pathogenesis and genetics of Parkinson's disease.14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria.α-Synuclein overexpression represses 14-3-3θ transcription.Identification of chaperones in a MPP+-induced and ATRA/TPA-differentiated SH-SY5Y cell PD model.Parkin, A Top Level Manager in the Cell's Sanitation Department.Regulation of Parkin E3 ubiquitin ligase activity.Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.14-3-3 proteins in neurological disorders.Neuroprotective function of 14-3-3 proteins in neurodegenerationGene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases.Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity.Moonlighting chaperone-like activity of the universal regulatory 14-3-3 proteins.Twenty years since the discovery of the parkin gene.Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase.Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.Age-Related Changes of 14-3-3 Isoforms in Midbrain of A53T-SNCA Overexpressing Mice.Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15.
P2860
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P2860
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
14-3-3eta is a novel regulator of parkin ubiquitin ligase
@nl
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@ast
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@en
type
label
14-3-3eta is a novel regulator of parkin ubiquitin ligase
@nl
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@ast
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@en
prefLabel
14-3-3eta is a novel regulator of parkin ubiquitin ligase
@nl
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@ast
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@en
P2093
P2860
P356
P1433
P1476
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
@en
P2093
Eri Sakata
Keiji Tanaka
Koichi Kato
Shigeto Sato
Tomoki Chiba
P2860
P304
P356
10.1038/SJ.EMBOJ.7600774
P407
P577
2005-08-11T00:00:00Z