Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
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HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradationTRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradationPhosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionParkin mono-ubiquitinates Bcl-2 and regulates autophagyp62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for bothAutoregulation of Parkin activity through its ubiquitin-like domainThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationDisease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagyUSP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondriaDistinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1AThe deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionAutophagy and the ubiquitin-proteasome system: collaborators in neuroprotectionParkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channelsLRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergyLinking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)Parkin Regulation and Neurodegenerative DisordersMolecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionMitochondrial dysfunction and oxidative stress in Parkinson's diseaseNiclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition14-3-3eta is a novel regulator of parkin ubiquitin ligase.Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutantThe parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesF-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagyDrp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivoAggresome formation and neurodegenerative diseases: therapeutic implicationsBRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradationParkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyThe novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancersThe ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunityParkin occurs in a stable, non-covalent, approximately 110-kDa complex in brainBassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradationRing finger protein 34 (RNF34) interacts with and promotes γ-aminobutyric acid type-A receptor degradation via ubiquitination of the γ2 subunitInteraction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosisParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinKelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 ComplexIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.Ubiquitin domain proteins in disease.
P2860
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P2860
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Parkin mediates nonclassical, ...... ations for Lewy body formation
@ast
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en-gb
Parkin mediates nonclassical, ...... ations for Lewy body formation
@nl
type
label
Parkin mediates nonclassical, ...... ations for Lewy body formation
@ast
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en-gb
Parkin mediates nonclassical, ...... ations for Lewy body formation
@nl
prefLabel
Parkin mediates nonclassical, ...... ations for Lewy body formation
@ast
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en-gb
Parkin mediates nonclassical, ...... ations for Lewy body formation
@nl
P2093
P50
P3181
P1476
Parkin mediates nonclassical, ...... ations for Lewy body formation
@en
P2093
Cheng Wang
Jeanne M M Tan
Kah Leong Lim
Kenny K K Chung
Ted M Dawson
Valina L Dawson
Wanli Smith
Yuji Tanaka
P304
P3181
P356
10.1523/JNEUROSCI.4474-04.2005
P407
P577
2005-02-01T00:00:00Z