A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
about
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining.Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network BiologyPathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signalingInteraction of LRRK2 with kinase and GTPase signaling cascadesCellular processes associated with LRRK2 function and dysfunctionGTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.A review of genome-wide transcriptomics studies in Parkinson's disease.Mutations in LRRK2 potentiate age-related impairment of autophagic flux.Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models.Regulating the regulators: Epigenetic, transcriptional, and post-translational regulation of RGS proteins.Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.
P2860
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P2860
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@ast
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en-gb
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@nl
type
label
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@ast
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en-gb
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@nl
prefLabel
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@ast
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en-gb
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@nl
P2093
P2860
P356
P1476
A Parkinson's disease gene reg ...... activity and neuronal toxicity
@en
P2093
Adamantios Mamais
Allison Citro
Benjamin Wolozin
Claudio Derada Troletti
James J Collins
Joon Y Boon
Julien Dusonchet
Katherine L Youmans
Klodjan Stafa
P2860
P304
P356
10.1093/HMG/DDU202
P407
P577
2014-09-15T00:00:00Z