High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction - Wikidata - awgldk - TriplyDB

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

http://www.wikidata.org/entity/Q27683539

about

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays.Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies Targeting protein-protein interactions as an anticancer strategy MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.Selective inhibitors of protein methyltransferases WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Epigenetics of hematopoiesis and hematological malignancies.Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.Mind the methyl: methyllysine binding proteins in epigenetic regulation.Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation.Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.Inhibitors of Protein Methyltransferases and Demethylases.Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex Targeting human SET1/MLL family of proteins.A chemical probe toolbox for dissecting the cancer epigenome.Writing, erasing and reading histone lysine methylations.RACK1 to the future--a historical perspective Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer.Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.IL-13 regulates human nasal epithelial cell differentiation via H3K4me3 modification.Computer-Aided Drug Design in Epigenetics.Facile target validation in an animal model with intracellularly expressed monobodies

P2860

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P2860

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

http://www.wikidata.org/entity/Q27683539

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

High-affinity, small-molecule ...... R5 protein-protein interaction

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High-affinity, small-molecule ...... R5 protein-protein interaction

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High-affinity, small-molecule ...... R5 protein-protein interaction

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High-affinity, small-molecule ...... R5 protein-protein interaction

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High-affinity, small-molecule ...... R5 protein-protein interaction

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Journal of the American Chemical Society

P1476

High-affinity, small-molecule ...... R5 protein-protein interaction

@en

P2093

Elizabeth C Townsend

http://www.w3.org/2001/XMLSchema#string

Fang Cao

http://www.w3.org/2001/XMLSchema#string

Hacer Karatas

http://www.w3.org/2001/XMLSchema#string

Liu Liu

http://www.w3.org/2001/XMLSchema#string

Ming Lei

http://www.w3.org/2001/XMLSchema#string

Yali Dou

http://www.w3.org/2001/XMLSchema#string

Yong Chen

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P2860

CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

Coot: model-building tools for molecular graphics

Phasercrystallographic software

Chromatin modifications and their function

P304

669-682

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scholarly article

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686616

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P356

10.1021/JA306028Q

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P407

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2

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135

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2012-12-27T00:00:00Z

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23210835

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5180416

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