LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
about
The associations between Parkinson's disease and cancer: the plot thickensThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainLRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesiasThe LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.Computational analysis of the LRRK2 interactome.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.LRRK2 Regulates Voltage-Gated Calcium Channel FunctionRegulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPasesLRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.The LRRK2 signalling system.Soluble Aβ1-42 increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing.Small-Molecule Inhibitors of LRRK2.Molecular Insights and Functional Implication of LRRK2 Dimerization.
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P2860
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
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2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@en
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@en-gb
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@nl
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@ast
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@en
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@en-gb
LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
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P50
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LRRK2 kinase activity regulate ...... LRRK2 macro-molecular complex
@en
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Antonella Marte
Franco Onofri
Maria D Cirnaru
Maria Passafaro
Michele Morari
P2860
P3181
P356
10.3389/FNMOL.2014.00049
P407
P50
P577
2014-01-01T00:00:00Z