Leucine rich repeat kinase 2

Leucine rich repeat kinase 2

Item
http://www.wikidata.org/entity/Q409961
Q21109320
sameAs
LRRK2
P688
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityLRRK2 controls synaptic vesicle storage and mobilization within the recycling poolImpaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic miceLeucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPLRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressExpression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model systemGTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's diseaseLRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activityBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersLRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexLRRK2 and the stress response: interaction with MKKs and JNK-interacting proteinsThe R1441C mutation of LRRK2 disrupts GTP hydrolysisKinase activity of mutant LRRK2 mediates neuronal toxicityLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportDominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutationARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2Insight into the mode of action of the LRRK2 Y1699C pathogenic mutantDysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2The role of oxidative stress in Parkinson's diseasePhosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationHomo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragmentLrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implicationsThe Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sitesRAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskMembrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationLRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junctionMutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathwaysThe familial Parkinsonism gene LRRK2 regulates neurite process morphologyAdult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S miceLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationLocalization of LRRK2 to membranous and vesicular structures in mammalian brainThe Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
P921
Q21144926-26DCF2E1-388E-45C0-A59E-0F6402D9AA6BQ22254785-BCC8EF2F-716D-420E-AAEF-939AE9E9E671Q24292798-2381F859-68CC-4DC4-B6A8-0398923695D6Q24293070-17872569-A289-4B4E-9424-E224FE9235F4Q24293723-9EB3DD86-66FD-4E15-A515-EF6625323EBCQ24294466-E3B38818-526E-46B2-9DC6-1F602A32924BQ24294684-0C7CB801-F957-414B-AF66-C61F581BAEE4Q24294785-FBCD8903-564E-426B-B464-2898D6C7F8D4Q24296778-3D79D4D4-BF12-45CA-9DF1-1E1A577130F2Q24297634-3CE6AD2D-64BB-4746-A6D0-90BD051AE546Q24298093-A77715B9-5364-48E0-AC5F-E5E5132902A2Q24298891-A79CAABD-7336-4C85-8A74-E3BE8091A75CQ24300440-2880861B-760B-4E45-B717-154AF9739193Q24303406-647E92A2-585D-4A1A-B5D5-23D241352BE8Q24303603-7229C7E9-0F9E-4108-96F7-2C29FA3E03E1Q24303851-8AED5381-FA14-44C6-941B-1C17297C0D56Q24305419-9D3DE21A-719F-4E99-9524-C889AEC65AD5Q24305448-06B650AE-6272-41C2-B4D4-2A9F69245B90Q24306167-0BAAFB57-48B0-4A7B-B9FE-4322D2D745D3Q24306788-E013E650-C722-41A8-A42D-C8563FE48364Q24307004-BFB897B0-DB0B-412E-BC76-AEF3C7BF0F8EQ24307455-02A41A25-EC1B-42B5-A165-D36C549174B4Q24307742-5EFCAE66-C433-4C14-A2EE-6938A03223CBQ24307946-D00ADF15-E1C1-464A-BAAD-3104676C832AQ24309417-9E5A4D28-8326-4278-A5A0-D95A397D7E79Q24310126-08306871-058D-4092-902A-81458A89F173Q24310262-1F000832-5C52-4F0A-9C09-48A9F4F82E5CQ24310608-2B622614-147D-4F7C-A7F3-5AEA71694443Q24313336-85BE9619-2546-4200-8B0C-496AC5EC0E59Q24315688-11C470EF-921B-40E9-BAC2-4BCA2B3F8311Q24316270-0038BD1A-B4A0-45E4-B2F7-495F536450F9Q24316894-E418446E-3775-45F0-9FA8-B92AD580BEC8Q24316917-F7D75FA4-4B96-4B15-8C8C-DB3B5850FB03Q24317613-8B5DC819-68C1-417F-BE35-CC0C4C01EF0EQ24317631-7D74F8EA-6D77-4E18-ABAF-9A72F302D5BDQ24317760-0C980EFD-4BDF-426B-95B6-501B49333811Q24318474-FE5B63EC-54EE-4D50-9DB4-EF74B3D7E2D4Q24318533-0AE4EA6B-DC2B-43DE-8205-18DC58852656Q24318643-1C372A27-D4B5-48B5-9A5C-A8C034C0E7B1Q24322792-F9C50BBA-9E0D-49C8-B198-111351F9360A
P921

Leucine rich repeat kinase 2

Item
http://www.wikidata.org/entity/Q409961
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Leucine rich repeat kinase 2
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Dardarina
@eu
Dardarina
@it
LRRK2
@cy
LRRK2
@en-ca
LRRK2
@en-gb
LRRK2
@fi
LRRK2
@uk
LRRK2
@zh
Leucine rich repeat kinase 2
@en
Leucine rich repeat kinase 2
@nl
type
label
Dardarina
@eu
Dardarina
@it
LRRK2
@cy
LRRK2
@en-ca
LRRK2
@en-gb
LRRK2
@fi
LRRK2
@uk
LRRK2
@zh
Leucine rich repeat kinase 2
@en
Leucine rich repeat kinase 2
@nl
altLabel
Dardarin
@de
Dardarin
@en
LRRK2
@de
LRRK2
@en
LRRK2
@es
LRRK2
@pt
augmented in rheumatoid arthritis 17
@en
leucine-rich repeat serine/threonine-protein kinase 2
@en
震顫素
@zh
prefLabel
Dardarina
@eu
Dardarina
@it
LRRK2
@cy
LRRK2
@en-ca
LRRK2
@en-gb
LRRK2
@fi
LRRK2
@uk
LRRK2
@zh
Leucine rich repeat kinase 2
@en
Leucine rich repeat kinase 2
@nl
P2888
P31
P352
P361
P527
P6366
P637
P638
P646
P680
P681
P682
P692
P702
P703
P705
P352
P6366
P637
P638
P646
P2888
P31
P352
P361
P527
P6366
P637
P638
P646
P680
P681
P682
P692
P702
P703
P705