The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateLeucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domainThe Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activityPathogenic LRRK2 negatively regulates microRNA-mediated translational repressionBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersHeterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson diseaseLRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenIdentification of potential protein interactors of Lrrk2The R1441C mutation of LRRK2 disrupts GTP hydrolysisARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsLRRK2 transport is regulated by its novel interacting partner Rab32Insight into the mode of action of the LRRK2 Y1699C pathogenic mutantLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationParkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3An early endosome regulator, Rab5b, is an LRRK2 kinase substrateMembrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationLRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junctionThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationThiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in DrosophilaThe Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegenerationMutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal deathThe G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationRole of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designThe regulation and deregulation of Wnt signaling by PARK genes in health and diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsMitochondrial dysfunction and oxidative stress in Parkinson's diseaseStructure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPaseLRRK2 at the interface of autophagosomes, endosomes and lysosomesStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsMitochondrial defects and oxidative stress in Alzheimer disease and Parkinson diseaseGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseIdentification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motifThe nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in DrosophilaEnhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019SSignal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity
P2860
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P2860
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The Parkinson disease causing ...... with increased kinase activity
@ast
The Parkinson disease causing ...... with increased kinase activity
@en
The Parkinson disease causing ...... with increased kinase activity
@nl
type
label
The Parkinson disease causing ...... with increased kinase activity
@ast
The Parkinson disease causing ...... with increased kinase activity
@en
The Parkinson disease causing ...... with increased kinase activity
@nl
prefLabel
The Parkinson disease causing ...... with increased kinase activity
@ast
The Parkinson disease causing ...... with increased kinase activity
@en
The Parkinson disease causing ...... with increased kinase activity
@nl
P2093
P50
P921
P3181
P356
P1476
The Parkinson disease causing ...... with increased kinase activity
@en
P2093
Annette Schumacher
Eric O'Neill
Norbert Kinkl
P304
P3181
P356
10.1093/HMG/DDI439
P407
P50
P577
2006-01-15T00:00:00Z