Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19
about
Structural diversity of eukaryotic membrane cytochrome p450sA Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational StatesClinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidationCorrelating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling.Streptomyces cytochromes P450: applications in drug metabolism.Use of density functional theory in drug metabolism studies.The role of drug metabolizing enzymes in clearance.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsMolecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity.Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin.Molecular dynamics investigations of regioselectivity of anionic/aromatic substrates by a family of enzymes: a case study of diclofenac binding in CYP2C isoforms.In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population.Interactions of omeprazole-based analogues with cytochrome P450 2C19: a computational study.The stereoselectivity of CYP2C19 on R- and S-isomers of proton pump inhibitors.Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.Identification of novel natural inhibitors of Opisthorchis felineus cytochrome P450 using structure-based screening and molecular dynamic simulation.Structure and Dynamics of Human Drug-Metabolizing Cytochrome P450 EnzymesKauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activityThe effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro
P2860
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P2860
Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural Characterization of Human Cytochrome P450 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
@en
Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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P2093
P2860
P921
P356
P1476
Structural characterization of ...... tween P450s 2C8, 2C9, and 2C19
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P2093
C David Stout
Eric F Johnson
R Leila Reynald
Stefaan Sansen
P2860
P304
P356
10.1074/JBC.M112.424895
P407
P577
2012-12-28T00:00:00Z