Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding
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Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenesStructural diversity of eukaryotic membrane cytochrome p450sAn open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolutionStructure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding siteCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat BoundStructural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenaseThe Halogen BondThe Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg DevelopmentStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Engineering of a water-soluble plant cytochrome P450, CYP73A1, and NMR-based orientation of natural and alternate substrates in the active site.Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substatesThe structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.[Metabolism of xenobiotics: beneficial and adverse effects].Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation.Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.Cytochrome P450: what have we learned and what are the future issues?Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Unusual regioselectivity and active site topology of human cytochrome P450 2J2Cytochrome P450 flexibilityStudies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11Substrate binding to cytochromes P450.Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase.Cooperative properties of cytochromes P450.Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.Plasticity of CYP2B enzymes: structural and solution biophysical methods.Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.Conformational plasticity and structure/function relationships in cytochromes P450.Halogen bonding in halocarbon-protein complexes: a structural survey.Tyrosine kinase inhibitors and drug interactions: a review with practical recommendations.Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsMolecular dynamics investigations of regioselectivity of anionic/aromatic substrates by a family of enzymes: a case study of diclofenac binding in CYP2C isoforms.State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.
P2860
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P2860
Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure of mammalian cytochr ...... fit model of substrate binding
@ast
Structure of mammalian cytochr ...... fit model of substrate binding
@en
Structure of mammalian cytochr ...... fit model of substrate binding
@nl
type
label
Structure of mammalian cytochr ...... fit model of substrate binding
@ast
Structure of mammalian cytochr ...... fit model of substrate binding
@en
Structure of mammalian cytochr ...... fit model of substrate binding
@nl
prefLabel
Structure of mammalian cytochr ...... fit model of substrate binding
@ast
Structure of mammalian cytochr ...... fit model of substrate binding
@en
Structure of mammalian cytochr ...... fit model of substrate binding
@nl
P2093
P356
P1433
P1476
Structure of mammalian cytochr ...... fit model of substrate binding
@en
P2093
C David Stout
Cristina Marques-Soares
Eric F Johnson
Michael R Wester
Patrick M Dansette
Sylvie Dijols
P304
P356
10.1021/BI034556L
P407
P577
2003-08-12T00:00:00Z