BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins - Wikidata - awgldk - TriplyDB

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

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Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT B cell antigen receptor signaling and internalization are mutually exclusive events.BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.Adaptors as central mediators of signal transduction in immune cells.B-cell antigen-receptor signalling in lymphocyte development.Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.B cell-associated immune profiles in patients with end-stage renal disease (ESRD)Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen Identification and characterisation of the immune response properties of Lampetra japonica BLNK.Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.Ca(2+) signaling in antigen receptor-activated B lymphocytes.Syk and pTyr'd: Signaling through the B cell antigen receptor B-lymphocyte calcium influx.Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.Assembly and Function of the Precursor B-Cell Receptor.Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.Concerted action of Helios and Ikaros controls the expression of the inositol 5-phosphatase SHIP.Identification and characterization of a novel BASH N terminus-associated protein, BNAS2.Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase.Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells.Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Role of Bruton's tyrosine kinase in B cells and malignancies.p-6Y-SYK phosphorylates BLNK (SLP65)

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

http://www.wikidata.org/entity/Q28216264

description

2002 nî lūn-bûn

@nan

2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

name

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@ast

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@en

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@nl

type

label

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@en

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@nl

prefLabel

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@ast

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@en

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@nl

P1433

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The EMBO Journal

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

@en

P2093

Andrew C Chan

http://www.w3.org/2001/XMLSchema#string

Christopher W Chiu

http://www.w3.org/2001/XMLSchema#string

Mark Dalton

http://www.w3.org/2001/XMLSchema#string

Masamichi Ishiai

http://www.w3.org/2001/XMLSchema#string

Tomohiro Kurosaki

http://www.w3.org/2001/XMLSchema#string

P2860

An essential role for BLNK in human B cell development

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation

BLNK: a central linker protein in B cell activation

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

Requirement for B cell linker protein (BLNK) in B cell development

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6461-6472

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scholarly article

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1991704

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10.1093/EMBOJ/CDF658

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P433

23

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21

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2002-12-01T00:00:00Z

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11012808

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12456653

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136961

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