Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity - Wikidata - awgldk - TriplyDB

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

http://www.wikidata.org/entity/Q28249985

about

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A Positive and negative regulation of T-cell activation through kinases and phosphatases A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation T cell activation RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors Interaction of SLP adaptors with the SH2 domain of Tec family kinases Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment The proline rich region of the Tec homology domain of ITK regulates its activity Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells Phosphorylation site dynamics of early T-cell receptor signaling Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase In vivo significance of ITK-SLP-76 interaction in cytokine production.SH2-dependent autophosphorylation within the Tec family kinase Itk.A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.Mechanism and functional significance of Itk autophosphorylation.Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Removal of C-terminal SRC kinase from the immune synapse by a new binding protein Itk phosphorylation sites are required for functional activity in primary T cells.Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.T-cell signaling regulated by the Tec family kinase, Itk.Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.Lipid signaling in T-cell development and function A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells Prolactin receptor signal transduction.Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.Disrupting the intermolecular self-association of Itk enhances T cell signaling.

P2860

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P2860

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

http://www.wikidata.org/entity/Q28249985

description

1997 nî lūn-bûn

@nan

1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Lck phosphorylates the activat ...... activates Itk kinase activity

@ast

Lck phosphorylates the activat ...... activates Itk kinase activity

@en

Lck phosphorylates the activat ...... activates Itk kinase activity

@nl

type

label

Lck phosphorylates the activat ...... activates Itk kinase activity

@ast

Lck phosphorylates the activat ...... activates Itk kinase activity

@en

Lck phosphorylates the activat ...... activates Itk kinase activity

@nl

prefLabel

Lck phosphorylates the activat ...... activates Itk kinase activity

@ast

Lck phosphorylates the activat ...... activates Itk kinase activity

@en

Lck phosphorylates the activat ...... activates Itk kinase activity

@nl

P1433

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P2860

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P921

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P356

JBC.272.40.25401

P1433

Journal of Biological Chemistry

P1476

Lck phosphorylates the activat ...... activates Itk kinase activity

@en

P2093

H M Wilcox

http://www.w3.org/2001/XMLSchema#string

L J Berg

http://www.w3.org/2001/XMLSchema#string

S D Heyeck

http://www.w3.org/2001/XMLSchema#string

P2860

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Regulatory intramolecular association in a tyrosine kinase of the Tec family

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

A novel human tyrosine kinase gene inducible in T cells by interleukin 2

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Identification of Itk/Tsk Src homology 3 domain ligands

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

P304

25401-25408

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.272.40.25401

http://www.w3.org/2001/XMLSchema#string

P407

P433

40

http://www.w3.org/2001/XMLSchema#string

P478

272

http://www.w3.org/2001/XMLSchema#string

P50

Stephen C Bunnell

P577

1997-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13910381

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P698

9312162

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P921

phosphorylation