ATR: a master conductor of cellular responses to DNA replication stress.
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P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsMicroRNA and signal transduction pathways in tumor radiation responseTopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive HematopoiesisIdentification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA ReplicationNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancersPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointDNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulationThe intersection between DNA damage response and cell death pathwaysOpposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathwayThe Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage.Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cellsATR autophosphorylation as a molecular switch for checkpoint activation.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.RPA and POT1: friends or foes at telomeres?Role of AKT signaling in DNA repair and clinical response to cancer therapy.HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damageRepair of naturally occurring mismatches can induce mutations in flanking DNA.Parvovirus infection-induced DNA damage responseHERC2-USP20 axis regulates DNA damage checkpoint through Claspin.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) SignalingTwo distinct modes of ATR activation orchestrated by Rad17 and Nbs1.p38MAPK and MK2 pathways are important for the differentiation-dependent human papillomavirus life cycle.Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication.VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiationSulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.LAMMER kinase contributes to genome stability in Ustilago maydis.Bridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S PhaseThe conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1.Cell-Type Specific Responses to DNA Replication Stress in Early C. elegans Embryos.
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ATR: a master conductor of cellular responses to DNA replication stress.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
ATR: a master conductor of cellular responses to DNA replication stress.
@en
ATR: a master conductor of cellular responses to DNA replication stress.
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type
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ATR: a master conductor of cellular responses to DNA replication stress.
@en
ATR: a master conductor of cellular responses to DNA replication stress.
@nl
prefLabel
ATR: a master conductor of cellular responses to DNA replication stress.
@en
ATR: a master conductor of cellular responses to DNA replication stress.
@nl
P2860
P1476
ATR: a master conductor of cellular responses to DNA replication stress.
@en
P2093
Rachel Litman Flynn
P2860
P304
P356
10.1016/J.TIBS.2010.09.005
P577
2010-10-12T00:00:00Z