Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene
about
Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cellsRetrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondriaMammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folatesTetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thalianaPolyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissuesAdditional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoterPurification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its geneHuman cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia.Transcription of the human folylpoly-gamma-glutamate synthetase gene.Tetrahydrofolate recognition by the mitochondrial folate transporter.Folates in Plants: Research Advances and Progress in Crop BiofortificationA mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expressionOrganization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme.Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.One-Carbon Metabolism in Health and Disease.Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of tFolate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase localized in mitochondria.Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis.
P2860
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P2860
Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Upstream organization of and m ...... amma-glutamate synthetase gene
@ast
Upstream organization of and m ...... amma-glutamate synthetase gene
@en
Upstream organization of and m ...... amma-glutamate synthetase gene
@en-gb
Upstream organization of and m ...... amma-glutamate synthetase gene
@nl
type
label
Upstream organization of and m ...... amma-glutamate synthetase gene
@ast
Upstream organization of and m ...... amma-glutamate synthetase gene
@en
Upstream organization of and m ...... amma-glutamate synthetase gene
@en-gb
Upstream organization of and m ...... amma-glutamate synthetase gene
@nl
prefLabel
Upstream organization of and m ...... amma-glutamate synthetase gene
@ast
Upstream organization of and m ...... amma-glutamate synthetase gene
@en
Upstream organization of and m ...... amma-glutamate synthetase gene
@en-gb
Upstream organization of and m ...... amma-glutamate synthetase gene
@nl
P2093
P2860
P356
P1476
Upstream organization of and m ...... amma-glutamate synthetase gene
@en
P2093
S J Freemantle
S M Taylor
P2860
P304
P356
10.1074/JBC.270.16.9579
P407
P577
1995-04-21T00:00:00Z