Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1
about
Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complexThe plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferasesMolecular basis for DPY-30 association to COMPASS-like and NURF complexesStructural basis for activity regulation of MLL family methyltransferasesThe MYC-WDR5 Nexus and CancerThe adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYCAn Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domainA non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexesFluorescence-based methods for screening writers and readers of histone methyl marks.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Substrate and product specificities of SET domain methyltransferasesWRAD: enabler of the SET1-family of H3K4 methyltransferases.ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genesA phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human.Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expressionEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation.SET for life: biochemical activities and biological functions of SET domain-containing proteinsPI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407.Every methyl counts--epigenetic calculus.The many facets of MLL1 regulation.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5.Targeting human SET1/MLL family of proteins.Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family.Evolving Catalytic Properties of the MLL Family SET Domain.Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5Assembling a COMPASS.Upon Infection the Cellular WD Repeat-containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication.Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.Moonlighting with WDR5: A Cellular Multitasker.Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.
P2860
Q24296678-8C3E875E-3076-49BC-B196-76511A09670CQ27676833-1D6EA5C0-5F29-42CD-BF02-5ED4F45DE693Q27696291-5F7DB316-BD91-40D9-B67F-74F43C88F798Q27704040-28898256-233C-4A13-AB92-6C2D588EE1E7Q28085683-A23F7CBE-044E-40B9-9423-0FB76BE32B61Q28118783-3CC1C4FF-643C-4957-AD22-7F2C1492EA6EQ28259591-923A1E28-8EC0-4A67-84F8-595774C02117Q33761102-5EA80F17-5FA7-4624-9269-04663C36EB89Q33789775-861122CD-866D-4EDF-B9EA-FC3221C6483EQ34040118-2550CDE3-2A0D-4220-A357-BE971D99C673Q34185471-5C01E9AD-915F-46CC-81B1-61C776676874Q34208487-3D767394-05CD-4D98-A09E-B003283E162AQ34278347-81B44167-0CC7-4759-BEB5-7C8AFFA1739BQ34531263-9E2F66F6-6ACA-4E0B-A701-BFDE49318EC0Q34981623-A6FE964B-0C52-4E11-8C1D-73DE1325B4B0Q35580822-EA2D81AF-5B68-459E-AE16-8776E22790F0Q35651409-47985452-E4BD-4EF1-94A9-99069D05F632Q35710023-013929AB-BCEC-4F74-A32D-408BB55A782CQ37578968-757E20AE-85FA-421B-BEB8-2CB4D597C5A0Q37603631-F4DC84E6-514B-4D6F-9806-C3914FC3DB79Q37615671-1AB2ABBD-7DC4-4CC1-A3D0-5B29F1E6641FQ37745350-EBC03517-40DC-4DEA-9E65-C8615E2E68BFQ37812416-8BD5F96E-8255-4E2C-9DE3-AE2B66C11C83Q38061869-378DB33B-ED46-4F3F-B30A-860E2B77B51CQ38161393-0BEA905B-147C-4956-9D22-4F3B5C08EF84Q38772574-BC9A81EC-86F5-4E47-B26B-A284D9A60E80Q38979643-CB5475A3-94FF-47C7-ADF5-E4C95F7D5DAAQ39147680-78299F06-C346-46A9-95B8-05D44B7D5825Q40593198-34E3D037-CBD6-478B-B02B-3C24B0B23559Q41848329-6B062465-4307-4BE8-B043-86ACCE6DDF74Q42141777-8B599AA5-25B8-4D9A-9178-636F1F94E090Q46323158-5F56E014-71A7-4B2E-A201-4D1C9465B578Q47295917-DD7126B4-F672-4315-968C-C544B8BDDDDCQ49550075-55681E92-42DD-4780-B789-5A0A367E0E45Q52369540-A422B352-1437-42C2-AAC6-F9FBF119DB09
P2860
Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@ast
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@en
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@nl
type
label
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@ast
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@en
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@nl
prefLabel
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@ast
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@en
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@nl
P2860
P3181
P356
P1476
Characterization of a Novel WD ...... xed Lineage Leukemia Protein-1
@en
P2093
Stacey M Southall
P2860
P304
P3181
P356
10.1074/JBC.M110.159921
P407
P50
P577
2010-10-22T00:00:00Z