A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
about
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligaseRegulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligaseTSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulationOverexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain functionNegative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1).Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cellsBiogenesis and function of multivesicular bodiesTsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesisBeta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2Characterization of rat BLOS2/Ceap, a putative yeast She3 homolog, as interaction partner of apoptosis antagonizing transcription factor/Che-1Tsg101, an inactive homologue of ubiquitin ligase e2, interacts specifically with human immunodeficiency virus type 2 gag polyprotein and results in increased levels of ubiquitinated gag.Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactionsLate domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch.Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell deathFunctional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysisOld world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transportp53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome.Viral late domainsIn vivo stabilization of the Dnmt1 (cytosine-5)- methyltransferase proteinBeta-arrestin and Mdm2, unsuspected partners in signaling from the cell surface.Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1Recent advances in the molecular diagnosis of lung cancer.Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops.Role of the TSG101 gene in Epstein-Barr virus late gene transcription.The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle production.Defective downregulation of receptor tyrosine kinases in cancerTSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression.Oncogenic breakdowns in endocytic adaptor proteins.P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies.Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting.PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected].TSGΔ154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions.
P2860
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P2860
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@ast
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@en
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@nl
type
label
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@ast
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@en
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@nl
prefLabel
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@ast
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@en
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@nl
P2093
P2860
P356
P1476
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
@en
P2093
P2860
P304
P356
10.1073/PNAS.98.4.1619
P407
P577
2001-02-13T00:00:00Z