Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin
about
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3Identification and characterization of functional domains in a mixed lineage kinase LZKMolecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brainPurification and characterization of a novel physiological substrate for calcineurin in mammalian cellsMixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergisticallyThe MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosisThe mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrateLocalization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cellsFyn binds to and phosphorylates the kidney slit diaphragm component NephrinRecruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activationMixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal developmentIsolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascadesNeph1 cooperates with nephrin to transduce a signal that induces actin polymerizationNephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.Axon regeneration requires a conserved MAP kinase pathway.Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site.The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regenerationAxon regeneration mechanisms: insights from C. elegansProtein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injuryUnzipping ion channels.Mixed-lineage kinase control of JNK and p38 MAPK pathways.Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoformPalmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinasesMixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLKJNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions.Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells.Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop.Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in ratsLoss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats.Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP.Intrathecal Injection of Dual Zipper Kinase shRNA Alleviating the Neuropathic Pain in a Chronic Constrictive Nerve Injury Model
P2860
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P2860
Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Characterization of dual leuci ...... depolarization via calcineurin
@ast
Characterization of dual leuci ...... depolarization via calcineurin
@en
Characterization of dual leuci ...... depolarization via calcineurin
@en-gb
Characterization of dual leuci ...... depolarization via calcineurin
@nl
type
label
Characterization of dual leuci ...... depolarization via calcineurin
@ast
Characterization of dual leuci ...... depolarization via calcineurin
@en
Characterization of dual leuci ...... depolarization via calcineurin
@en-gb
Characterization of dual leuci ...... depolarization via calcineurin
@nl
prefLabel
Characterization of dual leuci ...... depolarization via calcineurin
@ast
Characterization of dual leuci ...... depolarization via calcineurin
@en
Characterization of dual leuci ...... depolarization via calcineurin
@en-gb
Characterization of dual leuci ...... depolarization via calcineurin
@nl
P2093
P2860
P921
P3181
P356
P1476
Characterization of dual leuci ...... depolarization via calcineurin
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.271.28.16888
P407
P577
1996-07-12T00:00:00Z