Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells
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Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factorp56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainMona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphataseSignaling via Shc family adapter proteinsRoles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein ShcTargeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life spanSHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophagesThe proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsShc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIPPIP3 pathway in regulatory T cells and autoimmunityExpression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1A combined genetic and biochemical approach to mammalian signal transduction.The Grb2 adaptor.Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP.Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis.Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signalingActivation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signalingInsulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinasePhorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage eventsPhosphatases: the new brakes for cancer development?Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor.Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.Alterations in differentiation and behavior of monocytic phagocytes in transgenic mice that express dominant suppressors of ras signaling.A solution for stripping antibodies from polyvinylidene fluoride immunoblots for multiple reprobingColony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophagesDifferential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.
P2860
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P2860
Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@ast
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@en
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@nl
type
label
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@ast
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@en
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@nl
prefLabel
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@ast
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@en
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@nl
P2093
P2860
P356
P1476
Shc, Grb2, Sos1, and a 150-kil ...... ith Fms in hematopoietic cells
@en
P2093
K Carlberg
L R Rohrschneider
M N Lioubin
P2860
P304
P356
10.1128/MCB.14.9.5682
P407
P577
1994-09-01T00:00:00Z