Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. - Wikidata - awgldk - TriplyDB

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

http://www.wikidata.org/entity/Q24537136

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The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency Muscle wasting in myotonic dystrophies: a model of premature aging The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells The circadian clock in cancer development and therapy DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse The intersection between DNA damage response and cell death pathways Telomeres and human disease: ageing, cancer and beyond Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice.Ku86 preserves chromatin integrity in cells adapted to high NaCl.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Mechanisms of double-strand break repair in somatic mammalian cells.Do DNA Double-Strand Breaks Drive Aging?Metabolism, genomics, and DNA repair in the mouse aging liver.Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome Premature aging with impaired oxidative stress defense in mice lacking TR4.Need telomere maintenance? Call 911 Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.The life and death of DNA-PK.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection DNA double strand break repair, aging and the chromatin connection.Mild oxidative stress is beneficial for sperm telomere length maintenance DNA double-strand breaks: a potential causative factor for mammalian aging?Knockout of Ku86 accelerates cellular senescence induced by high NaCl.Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair Autophagy in DNA damage response The impact of base excision DNA repair in age-related neurodegenerative diseases Speeding up the clock: The past, present and future of progeria.The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.Aging of the Immune System. Mechanisms and Therapeutic Targets.In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span.DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.Looping-out mechanism for resolution of replicative stress at telomeres.The role of DNA-PK in aging and energy metabolism.PI3K-like kinases restrain Pim gene expression in endothelial cells.Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.

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Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

http://www.wikidata.org/entity/Q24537136

description

2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2004 թվականի ապրիլին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

@nl

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

@ast

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

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type

label

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

@nl

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

@ast

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

@en

prefLabel

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

@nl

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

@ast

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

@en

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SJ.EMBOR.7400127

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Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

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Juan Martín-Caballero

http://www.w3.org/2001/XMLSchema#string

Juana M Flores

http://www.w3.org/2001/XMLSchema#string

Marta Martín

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Peter Klatt

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Silvia Espejel

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P2860

Ku binds telomeric DNA in vitro

Ku is associated with the telomere in mammals

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

DNA double-strand breaks: signaling, repair and the cancer connection

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

The DNA-dependent protein kinase

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

DNA-PKcs is critical for telomere capping

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503-509

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10.1038/SJ.EMBOR.7400127

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