Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation
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Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator proteinEukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivoEIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophyDecreased guanine nucleotide exchange factor activity in eIF2B-mutated patientsMutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse waysOvarian failure related to eukaryotic initiation factor 2B mutations.Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulinMutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activityMechanisms of translational regulation by a human eIF5-mimic proteinStructure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueCrystal structure of eukaryotic translation initiation factor 2BA novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcoholsCharacterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiationThe yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranesBiochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchangeCree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locusEukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disordersA yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseEctopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesisIdentification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complexThe beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivoThe mechanism of eukaryotic translation initiation: new insights and challengesMinimum requirements for the function of eukaryotic translation initiation factor 2.An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationA multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition.OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation controlMechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.A new function and complexity for protein translation initiation factor eIF2BSaccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease.Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes.Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation.
P2860
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P2860
Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation
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2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Identification of domains and ...... ted by eIF2B complex formation
@ast
Identification of domains and ...... ted by eIF2B complex formation
@en
Identification of domains and ...... ted by eIF2B complex formation
@nl
type
label
Identification of domains and ...... ted by eIF2B complex formation
@ast
Identification of domains and ...... ted by eIF2B complex formation
@en
Identification of domains and ...... ted by eIF2B complex formation
@nl
prefLabel
Identification of domains and ...... ted by eIF2B complex formation
@ast
Identification of domains and ...... ted by eIF2B complex formation
@en
Identification of domains and ...... ted by eIF2B complex formation
@nl
P2860
P3181
P1476
Identification of domains and ...... ted by eIF2B complex formation
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.20.11.3965-3976.2000
P407
P577
2000-06-01T00:00:00Z