Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. - Wikidata - awgldk - TriplyDB

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

http://www.wikidata.org/entity/Q35167761

about

Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2 Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development Nedd4 controls animal growth by regulating IGF-1 signaling Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.Role of ubiquitination in IGF-1 receptor signaling and degradation.MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.Inhibition of TFII-I-dependent cell cycle regulation by p53.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma.Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function.Screening E3 substrates using a live phage display library The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin.MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells.Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.Role of insulin-like growth factor 1 receptor signalling in cancer.The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in Neuroblastoma DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination.MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.The ubiquitin ligase Nedd4 mediates oxidized low-density lipoprotein-induced downregulation of insulin-like growth factor-1 receptor Profiling of ubiquitin-like modifications reveals features of mitotic control.Role of IGF1R(+) MSCs in modulating neuroplasticity via CXCR4 cross-interaction.Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.Degradation of activated protein kinases by ubiquitination.Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy.

P2860

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P2860

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

http://www.wikidata.org/entity/Q35167761

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@ast

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@en

type

label

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@ast

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@en

prefLabel

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@ast

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@en

P1433

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P1476

Q35167761-9481CE7C-A000-41F9-A279-7B852336E3B1

P2093

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P2860

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Q35167761-841EC49A-B407-49A6-BE1D-9DA9BC03F981

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Q35167761-576212D9-24F3-4FAB-B75E-D7D3956057DE

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Q35167761-EF0CF1D3-5D76-4533-91C2-1BC3117FE7B0

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Q35167761-D26B1C97-4B71-429F-A999-BB6636A1F7E2

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P932

Q35167761-22E008F3-7599-456B-BD8B-38D4C665F1E9

P356

PNAS.1431613100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mdm2-dependent ubiquitination ...... like growth factor 1 receptor.

@en

P2093

Ada Girnita

http://www.w3.org/2001/XMLSchema#string

Leonard Girnita

http://www.w3.org/2001/XMLSchema#string

Olle Larsson

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

Induction of the growth inhibitor IGF-binding protein 3 by p53

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

Protein regulation by monoubiquitin

Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels.

P304

8247-8252

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1431613100

http://www.w3.org/2001/XMLSchema#string

P407

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P577

2003-06-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10694708

http://www.w3.org/2001/XMLSchema#string

P698

12821780

http://www.w3.org/2001/XMLSchema#string

P921

protein ubiquitination

P932

166214

http://www.w3.org/2001/XMLSchema#string