Defective downregulation of receptor tyrosine kinases in cancer
about
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionMultimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptorsUbiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppressionStructure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to HerceptinEpsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer ProgressionMass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells.Automated selection of regions of interest for intensity-based FRET analysis of transferrin endocytic trafficking in normal vs. cancer cellsCompartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulationGenetic structure and evolution of the Vps25 family, a yeast ESCRT-II component.Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo.The prognostic value of BRCA1 mRNA expression levels following neoadjuvant chemotherapy in breast cancer.The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing.Revisiting the hallmarks of cancer.Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalizedThe ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors.Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Fluorogen-activating proteins as biosensors of cell-surface proteins in living cellsCD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase CblShiga toxin regulates its entry in a Syk-dependent manner.The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation.Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationAn association study of polymorphisms in JAK3 gene with lung cancer in the Korean population.Development and thermodynamic evaluation of novel lipid raft stationary phase chromatography for screening potential antitumor agents.Systems biology and physical biology of clathrin-mediated endocytosis.FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced coloTissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia.Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer.Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer.Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.
P2860
Q24314826-15195262-AC4A-4000-BF78-18295B8C237CQ24339595-67AE47B9-2AC5-4D35-8341-94962F4F75E0Q24547253-04A672B6-F9E4-4699-B47F-0B6CE85F418CQ24671705-6DD2FC20-4434-456A-871A-84658E4D7624Q27006981-BBE18DB0-B607-4788-BC3B-32EA15E37695Q27644224-845303F7-953A-4956-9277-619B84921B35Q28247112-2A89F4E0-C0B4-4893-BA6C-20786B7A56BCQ28307353-C35AD605-B3EC-49E0-826A-0270F793ECB0Q30159530-1CD6D15B-C7A3-4550-9693-E63147CAE8B6Q30407485-78617EA9-9715-411D-83A3-1BF654DDF0C8Q30478189-34F7B38E-9D28-4DBD-BF5E-0AD9002898D9Q30834535-6663AFEE-31BA-4130-8978-290506158A55Q33252919-83AF710B-AB93-4D64-8D43-5ED45B1B365FQ33408460-848D921D-F0A7-444F-B77F-27569392C64FQ33538053-775A92AA-0EE7-406D-AADF-1F9EA0AE7911Q33565548-0CC1EF17-FB62-4981-A12B-827FF6C1BBCDQ33576337-08D162EF-E5A1-4CDF-8821-B80EF7DABE24Q33603037-C43A9BED-BD90-4CCE-BA97-2A0D8F3AB0CBQ33609045-18956E53-A420-4F34-83DB-67B099031561Q33732986-E7A6B7FC-47E3-4630-AB44-F870E716F0B3Q33779882-12FC3CF5-11C9-4F47-BF4E-12EF15C8BDF2Q33892755-AED4414D-5E8D-4E84-A1F1-CE2F5C6AE30DQ34097397-5EC88F9D-5F77-4F60-BBC5-E99A20C5D9EEQ34155877-034D09E4-D65D-436F-BA18-655E55EA43D1Q34282141-82A109E6-E5DF-430E-85FF-0E951649742EQ34407232-8B43BCA0-BA96-4469-89AB-94F592DCAEDEQ34479571-BDC2010D-EECC-4B50-A944-FF84D6165206Q35001415-9E3C8099-9A82-4DED-AEA1-3F865E2BE3BEQ35096609-54D29337-CE3C-407B-B840-F5DC3F12A10AQ35112995-CB3B701C-80CE-4F2A-8A5C-31BE89C77823Q35140616-B819C89F-5942-48EA-BCFC-0CB36A4ECA71Q35156394-F257AD5C-4963-4089-A942-0A2912482668Q35171987-ECE3CB6E-2D24-4E35-BF4C-0BAB96E939B9Q35677634-78BB4274-420A-4A17-B935-DDDF5D9B89C8Q35783030-A0124E9B-A330-43FE-A0C8-1E7FF470FEF5Q35806672-D0C115A2-A143-4D4B-BF73-A04662871195Q35928801-97686196-E96F-49F9-8E90-341E1A2558F6Q36044487-CAD1FE82-D6F5-442D-B752-A0C86BD89724Q36066649-6260023C-2455-497B-864C-DC923BE4436BQ36074307-08A1475D-EB15-483B-B42D-D6A2F24B0679
P2860
Defective downregulation of receptor tyrosine kinases in cancer
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Defective downregulation of receptor tyrosine kinases in cancer
@ast
Defective downregulation of receptor tyrosine kinases in cancer
@en
type
label
Defective downregulation of receptor tyrosine kinases in cancer
@ast
Defective downregulation of receptor tyrosine kinases in cancer
@en
prefLabel
Defective downregulation of receptor tyrosine kinases in cancer
@ast
Defective downregulation of receptor tyrosine kinases in cancer
@en
P2860
P356
P1433
P1476
Defective downregulation of receptor tyrosine kinases in cancer
@en
P2093
Kristi G Bache
Thomas Slagsvold
P2860
P304
P356
10.1038/SJ.EMBOJ.7600292
P407
P577
2004-07-01T00:00:00Z