Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
about
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complexIn vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- miceArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorderAssembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatasePIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasisA selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell deathPIKfyve: Partners, significance, debates and paradoxesArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionalityLoss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significanceCharcot-Marie-Tooth disease and intracellular trafficClass III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane trafficEndosome maturationPhosphoinositides: tiny lipids with giant impact on cell regulationMultiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.The Amyloid Precursor Protein Controls PIKfyve FunctionPI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamicsInhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathHemotin, a Regulator of Phagocytosis Encoded by a Small ORF and Conserved across MetazoansSns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptorMiz1 is required to maintain autophagic flux.Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functionsLipid kinases are essential for apicoplast homeostasis in Toxoplasma gondiiA dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptorsRegulation of TRPML1 function.Drosophila TRPML is required for TORC1 activationMutations in phosphoinositide metabolizing enzymes and human disease.Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.A novel mutation (p.Glu1389AspfsX16) of the phosphoinositide kinase, FYVE finger containing gene found in a Japanese patient with fleck corneal dystrophyAtg9 is required for intraluminal vesicles in amphisomes and autolysosomesCritical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.Fig4 deficiency: a newly emerged lysosomal storage disorder?Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.Endocytosis: a positive or a negative influence on Wnt signalling?
P2860
Q24307982-A051FFD2-6870-4BBC-B492-DA39CEAD6FF4Q24617439-7E93CF39-17D3-4014-9050-29EB6C85D710Q24618677-CE2A6463-5B2D-4745-9E32-87E488AEF54BQ24621406-AB19D93E-C07F-4104-B89A-7E85005626D2Q24643186-1129CEB3-2BE8-42CE-8F50-ED5186536F19Q24644277-08BC0B83-3AAD-4004-8421-06F25F97148FQ24645971-32CE222C-0D11-4821-89C7-D055D0F13E82Q24647545-0BF594C3-54C0-4D23-9975-FEB522083773Q24652827-C5955400-5911-4E4A-8996-ED9ADBC3A83DQ24657791-10AB327D-5AAE-4E78-B588-6D5B15D60B21Q24678783-B045743A-D851-4A01-959E-F27D87EAE8E5Q26823539-B1E6D926-AFF4-49B6-9654-086AF9115204Q26824841-8624989C-8FD5-4A8D-BE73-B54AD6EC46B9Q26865657-76EE26B9-0297-4983-9616-EC431503FA82Q26992067-2D3059F0-735E-4B4F-B022-961D38B2034CQ27012953-E5C0F272-C9F9-4528-89CE-E9093684E144Q27302039-2BA97B62-957F-4FED-B904-1DA1D0E84D99Q27303959-7A335626-AAE8-4E26-957E-7F8DE6A998DAQ27310309-DE01158F-CA59-4917-B5DE-B4EB31536D0BQ27314340-88BABF60-A204-4A19-AF1C-5E3939A797E3Q27314508-2E820BBB-7DB8-4FBA-AECB-DC89C1AEBF2FQ27331666-D4CB0E9B-4742-4EE8-BEC0-CAD9B6A8A9E9Q27345091-491FB601-65DB-4F05-B15D-2EDBDC538A0AQ30489644-4E762803-F128-48F9-BE6E-4F47A5EF7168Q33429561-B073339F-1FDC-4A57-9F6D-A7F1FBA66386Q33840072-DA701FDE-F20D-494A-AD10-DE0F484C8186Q33854521-1AD1915E-3943-48C4-BB0C-D21A32F1E96CQ34069981-AAC4BC09-11D0-4709-B226-CA3E1C431AFDQ35168572-89B34FFA-1E56-4D79-BDB2-81F7D1B50DC5Q35551486-820AB1B2-B1C0-4E93-9E01-E5D04881ED5AQ35640908-417AC945-CC52-4567-9864-ED1EC99B7FF6Q36236541-ED94DE2E-821B-42F6-B00E-CE56332F87DCQ36402106-CA6660A7-3406-4FA3-A455-E5508D6A0D09Q36492053-DBA65692-152C-4845-B508-E000CE4B0DE2Q36499572-D7B132D3-EC00-4475-99AB-A749D9C9A844Q36506704-F449637D-B1FB-467E-949A-883DAAA52871Q36583080-7BA0B2CF-2401-478C-98BD-61D398DCB230Q36592491-12F6561A-D749-464E-B6D5-B22D551E4804Q36877094-36D66F65-9B22-4863-A4A6-01CE3B5A2A47Q36956908-99B88060-6D93-4C3E-B4F3-FFF2501C0B96
P2860
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@ast
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@en
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@nl
type
label
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@ast
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@en
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@nl
prefLabel
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@ast
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@en
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@nl
P2093
P2860
P3181
P356
P1476
Fab1 phosphatidylinositol 3-ph ...... ncing of endocytosed receptors
@en
P2093
Andreas Brech
Camilla Englund
Christos Samakovlis
Krupa Pattni
Lina M W Rodahl
Stephen Dove
P2860
P304
P3181
P356
10.1091/MBC.E06-03-0239
P407
P577
2006-09-01T00:00:00Z