Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity
about
The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cellsALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic diseaseActivin receptor-like kinases: a diverse family playing an important role in cancerActivin B receptor ALK7 is a negative regulator of pancreatic beta-cell functionProgramming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetesRegulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signalingNod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Differential gene expression between neuropeptide Y expressing neurons of the dorsomedial nucleus of the hypothalamus and the arcuate nucleus: microarray analysis study.NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism.Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesityGrowth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditureNodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesisDeficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.Mitochondrial dysfunction in obesityActivin signaling as an emerging target for therapeutic interventionsActivin signaling: effects on body composition and mitochondrial energy metabolismALK7 gene polymorphism is associated with metabolic syndrome risk and cardiovascular remodelingIdentification and expression of Smads associated with TGF-β/activin/nodal signaling pathways in the rainbow trout (Oncorhynchus mykiss).Conserved genetic pathways associated with microphthalmia, anophthalmia, and coloboma.CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivoTGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.Activins and Inhibins: Roles in Development, Physiology, and Disease.Agonists and Antagonists of TGF-β Family Ligands.TGF-β Family Signaling in Drosophila.GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.ALK7 protects against pathological cardiac hypertrophy in mice.A novel therapeutic approach to treating obesity through modulation of TGFβ signaling.Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes.Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα.A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte functionExpression of activin receptor-like kinase 7 in adipose tissues.Toward a better understanding of the interaction between TGF-β family members and their ALK receptors.Changes in human adipose tissue gene expression during diet-induced weight loss.Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner.Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
P2860
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P2860
Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Growth/differentiation factor ...... issue and diet-induced obesity
@ast
Growth/differentiation factor ...... issue and diet-induced obesity
@en
Growth/differentiation factor ...... issue and diet-induced obesity
@nl
type
label
Growth/differentiation factor ...... issue and diet-induced obesity
@ast
Growth/differentiation factor ...... issue and diet-induced obesity
@en
Growth/differentiation factor ...... issue and diet-induced obesity
@nl
prefLabel
Growth/differentiation factor ...... issue and diet-induced obesity
@ast
Growth/differentiation factor ...... issue and diet-induced obesity
@en
Growth/differentiation factor ...... issue and diet-induced obesity
@nl
P2093
P2860
P921
P356
P1476
Growth/differentiation factor ...... issue and diet-induced obesity
@en
P2093
Carlos F Ibáñez
Eva Reissmann
Olov Andersson
Philippe Bertolino
P2860
P304
P356
10.1073/PNAS.0800272105
P407
P577
2008-05-14T00:00:00Z