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Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexesNovel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactionsA novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acidsStaphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activationStructural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junctionSegregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activationActive site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shearRatcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generationInhibition of thrombin formation by active site mutated (S360A) activated protein C.Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism.Engineering streptokinase for generation of active site-labeled plasminogen analogs.In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activationNotecarin D binds human factor V and factor Va with high affinity in the absence of membranes.Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains.Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes.Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.The role of thrombin exosites I and II in the activation of human coagulation factor V.Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasminStructural basis for reduced staphylocoagulase-mediated bovine prothrombin activationExosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine ModelCharacterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation.Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombinFull time course kinetics of the streptokinase-plasminogen activation pathway.Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.Development of coagulation factor probes for the identification of procoagulant circulating tumor cells.Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation.Efficacy, tolerability and safety of propiverine hydrochloride in comparison to oxybutynin in children with urge incontinence due to overactive bladder: Results of a multicentre observational cohort study.Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin.Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin.Coupling of conformational and proteolytic activation in the kinetic mechanism of plasminogen activation by streptokinase.Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase.Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.Carbon and amide detect backbone assignment methods of a novel repeat protein from the staphylocoagulase in S. aureus.Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.
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name
Paul E Bock
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type
label
Paul E Bock
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prefLabel
Paul E Bock
@en