Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. - Wikidata - awgldk - TriplyDB

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

http://www.wikidata.org/entity/Q27930743

about

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis PIKfyve: Partners, significance, debates and paradoxes ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Charcot-Marie-Tooth disease and intracellular traffic Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease Phosphoinositides: tiny lipids with giant impact on cell regulation Phosphoinositides in the mammalian endo-lysosomal network The Amyloid Precursor Protein Controls PIKfyve Function The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.Molecular Bases of Multimodal Regulation of a Fungal Transient Receptor Potential (TRP) Channel Cardiolipin mediates cross-talk between mitochondria and the vacuole.Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane.Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1 Novel components of an active mitochondrial K(+)/H(+) exchange.The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion.Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body.Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements.

P2860

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P2860

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

http://www.wikidata.org/entity/Q27930743

description

2002 nî lūn-bûn

@nan

2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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type

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... ator of the lipid kinase Fab1p

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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Journal of Cell Biology

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Osmotic stress-induced increas ...... tor of the lipid kinase Fab1p.

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P2093

Andrew E Wurmser

http://www.w3.org/2001/XMLSchema#string

Cecilia J Bonangelino

http://www.w3.org/2001/XMLSchema#string

Jason E Duex

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Johnathan J Nau

http://www.w3.org/2001/XMLSchema#string

Jonathan D Gary

http://www.w3.org/2001/XMLSchema#string

Lois S Weisman

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Mikala Brinkman

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Scott D Emr

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P2860

Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast

Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology

Basic local alignment search tool

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.

Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

Aquaporins in Saccharomyces: Characterization of a second functional water channel protein

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome.

P304

1015-28

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P31

scholarly article

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4721497

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P356

10.1083/JCB.200201002

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P407

P433

6

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P478

156

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2002-03-18T00:00:00Z

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P5875

11474433

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P698

11889142

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P921

Vac14 homolog (S. cerevisiae)

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2173454

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