Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens
about
HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cellsMapping functional regions in the lumenal domain of the class II-associated invariant chainThe invariant chain is required for intracellular transport and function of major histocompatibility complex class II moleculesDefective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expressionStructure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chainStructural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide bindingA role for calnexin (IP90) in the assembly of class II MHC moleculesInvariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1Pathways of antigen processing.Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.Stoichiometry of HLA class II-invariant chain oligomersDirect observation of disordered regions in the major histocompatibility complex class II-associated invariant chain.Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartmentsProtein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsRelationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexesA lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.The cell biology of antigen processing.Distinct binding sites on HLA-DR for invariant chain and staphylococcal enterotoxins.Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.Toward a Network Model of MHC Class II-Restricted Antigen Processing.Trimeric interactions of the invariant chain and its association with major histocompatibility complex class II alpha beta dimers.Long-Peptide Cross-Presentation by Human Dendritic Cells Occurs in Vacuoles by Peptide Exchange on Nascent MHC Class I Molecules.Mechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications.The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function.Invariant Chain Complexes and Clusters as Platforms for MIF Signaling.Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules.An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulumAssembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules.
P2860
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P2860
Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens
description
1990 nî lūn-bûn
@nan
1990 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Invariant chain trimers are se ...... ion with HLA class II antigens
@ast
Invariant chain trimers are se ...... ion with HLA class II antigens
@en
Invariant chain trimers are se ...... ion with HLA class II antigens
@nl
type
label
Invariant chain trimers are se ...... ion with HLA class II antigens
@ast
Invariant chain trimers are se ...... ion with HLA class II antigens
@en
Invariant chain trimers are se ...... ion with HLA class II antigens
@nl
prefLabel
Invariant chain trimers are se ...... ion with HLA class II antigens
@ast
Invariant chain trimers are se ...... ion with HLA class II antigens
@en
Invariant chain trimers are se ...... ion with HLA class II antigens
@nl
P2093
P2860
P356
P1476
Invariant chain trimers are se ...... ion with HLA class II antigens
@en
P2093
P2860
P304
P356
10.1083/JCB.111.3.839
P407
P577
1990-09-01T00:00:00Z