Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action - Wikidata - awgldk - TriplyDB

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

http://www.wikidata.org/entity/Q24683017

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PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD The PEA-15 protein regulates autophagy via activation of JNK Evidence of a large-scale functional organization of mammalian chromosomes On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 Akt regulates drug-induced cell death through Bcl-w downregulation ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.Antagonism of tumoral prolactin receptor promotes autophagy-related cell death.Bimodal regulation of FoxO3 by AKT and 14-3-3 Temporal changes in gene expression after injury in the rat retina An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Cell fate decisions are specified by the dynamic ERK interactome.Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.Estradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injury Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer.Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15).Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer.Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation.Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death.Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.Targetting PED/PEA-15 for diabetes treatment.Proteome-wide analysis of temporal phosphorylation dynamics in lysophosphatidic acid-induced signaling.Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury.

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Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

http://www.wikidata.org/entity/Q24683017

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

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Protein kinase B/Akt binds and ...... izing its antiapoptotic action

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Protein kinase B/Akt binds and ...... izing its antiapoptotic action

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type

label

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

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Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@en

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@nl

prefLabel

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@ast

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@en

Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@nl

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P356

MCB.23.13.4511-4521.2003

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Molecular and Cellular Biology

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Protein kinase B/Akt binds and ...... izing its antiapoptotic action

@en

P2093

Alessandra Trencia

http://www.w3.org/2001/XMLSchema#string

Angela Cassese

http://www.w3.org/2001/XMLSchema#string

Anna Perfetti

http://www.w3.org/2001/XMLSchema#string

Claudia Miele

http://www.w3.org/2001/XMLSchema#string

Ferdinando Giacco

http://www.w3.org/2001/XMLSchema#string

Francesco Beguinot

http://www.w3.org/2001/XMLSchema#string

Francesco Oriente

http://www.w3.org/2001/XMLSchema#string

Gerolama Condorelli

http://www.w3.org/2001/XMLSchema#string

Giovanni Vigliotta

http://www.w3.org/2001/XMLSchema#string

Pietro Formisano

http://www.w3.org/2001/XMLSchema#string

P2860

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

Bcl-2 targets the protein kinase Raf-1 to mitochondria

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

Identification of 14-3-3zeta as a protein kinase B/Akt substrate

P304

4511-21

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scholarly article

P356

10.1128/MCB.23.13.4511-4521.2003

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13

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23

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2003-07-01T00:00:00Z

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10707247

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12808093

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P921

apoptotic process

phosphorylation

P932

164852

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