Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD - Wikidata - awgldk - TriplyDB

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

http://www.wikidata.org/entity/Q24531859

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The PEA-15 protein regulates autophagy via activation of JNK On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities FLIP and the death effector domain family Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α(2)-adrenoceptors and extracellular signal-regulated kinases ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Effects of environmental tobacco smoke on adult rat brain biochemistry.The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Species-specific microRNA roles elucidated following astrocyte activation.Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Death pathways triggered by activated Ras in cancer cells Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism Estradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injury Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer.Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.Ras and rheb signaling in survival and cell death PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.Targetting PED/PEA-15 for diabetes treatment.Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury.Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.Chaperone-mediated autophagy substrate proteins in cancer.PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.PEA-15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia.NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites.Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.Nonapoptotic functions of Fas/CD95 in the immune response.

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Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

http://www.wikidata.org/entity/Q24531859

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@ast

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en-gb

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@nl

type

label

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@ast

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en-gb

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@nl

prefLabel

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@ast

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en-gb

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@nl

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P1433

Biochemical Journal

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Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

@en

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Anna Knapinska

http://www.w3.org/2001/XMLSchema#string

Hema Vaidyanathan

http://www.w3.org/2001/XMLSchema#string

Hemamalini Renganathan

http://www.w3.org/2001/XMLSchema#string

P2860

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

RSK2 activity is regulated by its interaction with PEA-15

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

Characterization of PEA-15, a major substrate for protein kinase C in astrocytes

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

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729-35

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10.1042/BJ20050378

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P433

Pt 3

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390

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2005-09-15T00:00:00Z

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7824286

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15916534

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phosphorylation

P932

1199667

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