Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis
about
Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDProtein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionAstrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study.On the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesRecognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domainVanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activationERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.A new caspase-8 isoform caspase-8s increased sensitivity to apoptosis in Jurkat cellsPhosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosisThe death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Species-specific microRNA roles elucidated following astrocyte activation.Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismA phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.C5a-induced gene expression in human umbilical vein endothelial cells.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismEstradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injuryMitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer.Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15).An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucomaPTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis.Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.The role of microRNAs in the regulation of apoptosis in lung cancer and its application in cancer treatmentCyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.Chaperone-mediated autophagy substrate proteins in cancer.PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.PEA-15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia.Identification and characterization of DEDDL, a human-specific isoform of DEDD.
P2860
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P2860
Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@ast
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@en
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@nl
type
label
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@ast
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@en
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@nl
prefLabel
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@ast
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@en
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@nl
P2093
P1476
Knock-out of the neural death ...... rom TNFalpha-induced apoptosis
@en
P2093
D Kitsberg
E Formstecher
H Chneiweiss
P304
P407
P577
1999-10-01T00:00:00Z