Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
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Induction of bilirubin clearance by the constitutive androstane receptor (CAR)Diurnal difference in CAR mRNA expressionAlternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorModulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR for metabolic diseasesNuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateIn vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CARInduction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liverInactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.Activation of xenobiotic receptors: driving into the nucleus.Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicityCAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissuesA functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Cytochrome P450 and xenobiotic receptor humanized mice.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesProteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral countingPolyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3Predicting inductive drug-drug interactions.Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Drug-activated nuclear receptors CAR and PXR.Acetaminophen intoxication and length of treatment: how long is long enough?Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer.The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA.Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in miceIdentification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendiumActivation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicityLentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.Small-molecule modulators of the constitutive androstane receptor.
P2860
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P2860
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@ast
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@en
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@nl
type
label
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@ast
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@en
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@nl
prefLabel
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@ast
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@en
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@nl
P2093
P3181
P356
P1433
P1476
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
@en
P2093
David D Moore
Steven S Chua
Wendong Huang
P3181
P356
10.1126/SCIENCE.1073502
P407
P577
2002-10-11T00:00:00Z