A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.
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Developments in renal pharmacogenomics and applications in chronic kidney diseaseHistone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilizationGene expression variability in human hepatic drug metabolizing enzymes and transportersAlterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactionsCAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Overcoming drug resistance by regulating nuclear receptors.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.Binary and ternary combinations of anti-HIV protease inhibitors: effect on gene expression and functional activity of CYP3A4 and efflux transporters.Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.Role of CAR and PXR in xenobiotic sensing and metabolism.Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs.Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.Compartment-specific gene regulation of the CAR inducer efavirenz in vivo.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.A new model for studying tissue-specific mdr1a gene expression in vivo by live imagingAcetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanismCYP3A5 and ABCB1 genes and hypertension.Signaling control of the constitutive androstane receptor (CAR)Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters (Review)Regulation of gene expression by CAR: an update.ECOTOXICOLOGICAL PROPERTIES OF KETOPROFEN AND THE S(+)-ENANTIOMER (DEXKETOPROFEN): BIOASSAYS IN FRESHWATER MODEL SPECIES AND BIOMARKERS IN FISH PLHC-1 CELL-LINE.Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line.Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line.Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells.Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.The effect of vitamin D3 and ketoconazole combination on VDR-mediated P-gp expression and function in human colon adenocarcinoma cells: implications in drug disposition and resistance.Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.Constitutive androstane receptor regulates the intestinal mucosal response to injury.Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
P2860
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P2860
A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A role for constitutive andros ...... an intestinal MDR1 expression.
@en
type
label
A role for constitutive andros ...... an intestinal MDR1 expression.
@en
prefLabel
A role for constitutive andros ...... an intestinal MDR1 expression.
@en
P2093
P2860
P356
P1433
P1476
A role for constitutive andros ...... an intestinal MDR1 expression.
@en
P2093
Anke Geick
Heike Tegude
Katja A Arnold
Michel Eichelbaum
Oliver Burk
P2860
P304
P356
10.1515/BC.2005.060
P577
2005-06-01T00:00:00Z