Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor
about
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientationA highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHCStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-EDisparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding MechanismPeptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.In vitro evolution of a T cell receptor with high affinity for peptide/MHC.Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA.PhosphoThr peptide binding globally rigidifies much of the FHA domain from Arabidopsis receptor kinase-associated protein phosphataseStabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins.Rational design of T cell receptors with enhanced sensitivity for antigen.Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display.Solution mapping of T cell receptor docking footprints on peptide-MHC.Measurement of ¹⁵N relaxation rates in perdeuterated proteins by TROSY-based methodsRole of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexesMapping the energy of superantigen Staphylococcus enterotoxin C3 recognition of an alpha/beta T cell receptor using alanine scanning mutagenesis.Structural and kinetic basis for heightened immunogenicity of T cell vaccines.Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.Backbone resonance assignment of N15, N30 and D10 T cell receptor β subunits.Cross-reactivity of T cells and its role in the immune systemA role for "self" in T-cell activationVaccination with single chain antigen receptors for islet-derived peptides presented on I-A(g7) delays diabetes in NOD mice by inducing anergy in self-reactiveT-cells.Protein dynamics and the immunological evolution of molecular recognition.Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunitiesConformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility.Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.Two-step binding mechanism for T-cell receptor recognition of peptide MHC.NMR spectroscopy reveals unexpected structural variation at the protein-protein interface in MHC class I molecules.Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide.
P2860
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P2860
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Structure, specificity and CDR ...... d single-chain T-cell receptor
@ast
Structure, specificity and CDR ...... d single-chain T-cell receptor
@en
Structure, specificity and CDR ...... d single-chain T-cell receptor
@nl
type
label
Structure, specificity and CDR ...... d single-chain T-cell receptor
@ast
Structure, specificity and CDR ...... d single-chain T-cell receptor
@en
Structure, specificity and CDR ...... d single-chain T-cell receptor
@nl
prefLabel
Structure, specificity and CDR ...... d single-chain T-cell receptor
@ast
Structure, specificity and CDR ...... d single-chain T-cell receptor
@en
Structure, specificity and CDR ...... d single-chain T-cell receptor
@nl
P2093
P356
P1476
Structure, specificity and CDR ...... d single-chain T-cell receptor
@en
P2093
P304
P356
10.1038/9359
P577
1999-06-01T00:00:00Z