Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
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Crystal Structure of the Erythromycin Polyketide Synthase DehydrataseStructure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic PathwayCrystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic PathwayStructure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesisBiochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide HydrolaseStructure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolorStructural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic PathwaysThe methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesisStructural enzymology of polyketide synthases.Insights from the sea: structural biology of marine polyketide synthasesProfile of Robert M. Stroud.Modeling linear and cyclic PKS intermediates through atom replacement.The enzymology of combinatorial biosynthesis.Combinatorial biosynthesis of reduced polyketides.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.The type I fatty acid and polyketide synthases: a tale of two megasynthasesKetide Synthase (KS) Domain Prediction and Analysis of Iterative Type II PKS Gene in Marine Sponge-Associated Actinobacteria Producing Biosurfactants and Antimicrobial AgentsA polyketide macrolactone synthase from the filamentous fungus Gibberella zeaeMechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.Structural analysis of protein-protein interactions in type I polyketide synthasesStructural insights into nonribosomal peptide enzymatic assembly linesPKS and NRPS release mechanisms.Thioesterases: a new perspective based on their primary and tertiary structures.Frontiers and opportunities in chemoenzymatic synthesis.The structures of type I polyketide synthases.Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide.The structural biology of biosynthetic megaenzymes.Structure and mechanism of assembly line polyketide synthases.Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin.Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3.A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteinsAnalysis of the Sequences, Structures, and Functions of Product-Releasing Enzyme Domains in Fungal Polyketide Synthases.Structure of a modular polyketide synthase.Substrate controlled divergence in polyketide synthase catalysis.Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase.Type II thioesterase ScoT, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference for propionate.Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain.
P2860
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P2860
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
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2002 nî lūn-bûn
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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Insights into channel architec ...... f modular polyketide synthases
@ast
Insights into channel architec ...... f modular polyketide synthases
@en
Insights into channel architec ...... f modular polyketide synthases
@nl
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label
Insights into channel architec ...... f modular polyketide synthases
@ast
Insights into channel architec ...... f modular polyketide synthases
@en
Insights into channel architec ...... f modular polyketide synthases
@nl
prefLabel
Insights into channel architec ...... f modular polyketide synthases
@ast
Insights into channel architec ...... f modular polyketide synthases
@en
Insights into channel architec ...... f modular polyketide synthases
@nl
P2093
P356
P1433
P1476
Insights into channel architec ...... f modular polyketide synthases
@en
P2093
Chaitan Khosla
David E Cane
Hongxiang Lu
Robert M Stroud
Shiou-Chuan Tsai
P304
P356
10.1021/BI0260177
P407
P577
2002-10-22T00:00:00Z