Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism - Wikidata - awgldk - TriplyDB

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

http://www.wikidata.org/entity/Q27641100

about

sameAs

Computational methods in drug discovery Targeting xenobiotic receptors PXR and CAR in human diseases Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721 Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice Active nuclear receptors exhibit highly correlated AF-2 domain motions Evolution of pharmacologic specificity in the pregnane X receptor.The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor Understanding nuclear receptors using computational methods.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Pregnane X receptor and drug-induced liver injury.Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins.Small-molecule modulators of PXR and CAR.Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.Carboxylesterases are uniquely expressed among tissues and regulated by nuclear hormone receptors in the mouse.PXR antagonists and implication in drug metabolism.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Evolution of the bile salt nuclear receptor FXR in vertebrates Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR Machine learning methods and docking for predicting human pregnane X receptor activation.Structural basis of human pregnane X receptor activation by the hops constituent colupulone Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.The structural basis of pregnane X receptor binding promiscuity.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Medicinal applications of perfluoroalkylated chain-containing compounds.Affinity purification using recombinant PXR as a tool to characterize environmental ligands.Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding.Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition.PXR ligand classification model with SFED-weighted WHIM and CoMMA descriptors.

P2860

Q26997089-BB34E915-6515-4930-BB32-DCEB438D5982 Q27012669-A1236D43-EBF8-46A2-AFE7-5545E5ED55E7 Q27671326-0784B711-B2C4-40A9-8C96-2ACBFB25CBE6 Q28472135-167F305A-180B-4FC3-9FED-BB4C28043649 Q28730803-0D7B5106-01FA-4F55-ADF0-90A9248D65AA Q30391745-B51929EC-DC8A-421E-A3EF-2A06D7A9368B Q30426995-66F71BBC-DEA8-43A4-A429-95786A9AB520 Q30845026-005635A5-1DFF-4D71-AE5A-B01BD0476CAD Q33326759-165125BA-BAED-4936-B45B-46762AD2785C Q33642959-43D918C5-334A-436E-8B98-CE4E5F2A24B2 Q33755918-8D40339F-9830-4841-9A88-3C9113CF9AD7 Q33756500-A08E7468-1924-4933-B376-54586934FA43 Q33811323-F4FCB7E2-D5DD-4695-93A4-35D5A4D9F7A1 Q33991958-41EC2EFB-7D49-4871-906C-401B386886C1 Q34128854-EA3BB85B-B801-44F9-8313-4A163F07921A Q34196976-7C1ACAA0-4ECC-4EA6-B5FD-2D96A2BB781B Q34215650-B83CBDA5-5A77-4F27-98D6-12E814F20F1F Q34345049-7DE1E5F3-EECC-403A-A472-18CF4A46DBEC Q35288427-E563ADB4-BBC0-4771-A364-77ADE2AEF562 Q35848854-E1A1352B-270D-4F89-AD66-BCD1E28EB759 Q35938150-491692D4-B6B3-4558-AB85-B474DEC0F459 Q36148858-46474991-5780-461A-B323-0A5F0B833B3A Q36497659-00308353-9546-48A9-83FD-4A79AB5ACAF3 Q36640752-40C752F1-8E79-4CE6-BAD6-8D1CF30C3881 Q36652012-B1CAC7D5-6DD8-404C-B7C8-F56EE73C5BEF Q36727402-74AB7C18-74FF-4DD1-84FF-342DC28799DD Q36832670-32E5D437-3C57-4400-8DD2-3BE6B2F0F0A9 Q36951921-E3F9EA6B-21F3-4FC4-B938-39D02BF42361 Q36976887-CBF8FEB6-5935-40CB-AB4A-34F08D336BBD Q37124197-BFB5D3BE-531D-426F-B802-557D71EEE717 Q37303129-74987920-EE80-41BF-B70A-1A5859BB842B Q37400616-6A647F76-EA8B-4EF2-967C-3A85E2E2C865 Q37461507-D2227539-4E80-47A4-9556-B817628D9553 Q38076345-A81A9FC3-D084-4DB1-9C39-2D7D7CC1D2AA Q38235504-2D0CD8E5-E2C0-440F-B356-09024544C05C Q39416595-41FE6144-FD9C-4CC1-A414-57EBF4096DED Q41220497-8115683B-52B8-49D4-B351-3EDF6DA9D3E1 Q42237279-9C6C7B1B-4DA1-4A86-8118-BAD5400D66FF Q43129908-76B2FD2D-21F5-443B-9BD2-881975247B09 Q45960608-A6352545-2098-4DA6-A10F-B8DA307F175D

P2860

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

http://www.wikidata.org/entity/Q27641100

description

2007 nî lūn-bûn

@nan

2007 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի մարտին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Crystal structure of the PXR–T ...... ential for receptor antagonism

@ast

Crystal structure of the PXR–T ...... ential for receptor antagonism

@en

Crystal structure of the PXR–T ...... ential for receptor antagonism

@nl

type

label

Crystal structure of the PXR–T ...... ential for receptor antagonism

@ast

Crystal structure of the PXR–T ...... ential for receptor antagonism

@en

Crystal structure of the PXR–T ...... ential for receptor antagonism

@nl

prefLabel

Crystal structure of the PXR–T ...... ential for receptor antagonism

@ast

Crystal structure of the PXR–T ...... ential for receptor antagonism

@en

Crystal structure of the PXR–T ...... ential for receptor antagonism

@nl

P1433

Q27641100-9D9AFD92-C02C-4BC9-8AA0-4D5DB73B8CFD

P1476

Q27641100-25991104-954C-40DC-9A23-996D6834B4F5

P2093

Q27641100-778B5D1B-2DDF-4940-B832-9E143B1EF067

Q27641100-9450A84F-A2C4-4DE3-9901-7A4383888C5A

Q27641100-A6A30644-8C1D-47DA-9D20-97CFCB28597E

Q27641100-B143DAFA-6FAB-42BC-886B-114842F46908

Q27641100-F8B807F9-C1A8-45E1-9BD1-5A1D6A804F28

P2860

Q27641100-024EFFA5-C80D-4490-A476-A02286DC3B44

Q27641100-147244CD-7EB8-4FE9-9F4F-957758657D7C

Q27641100-1EBF1507-B4C7-44A5-9461-12931BE86764

Q27641100-21881662-A7EE-490E-B6C3-37DE48B2F0A3

Q27641100-235F8977-6DE0-4CEC-8D1D-1FE767D3C12E

Q27641100-238A16DA-0B5E-4DC5-B17B-FCF737562383

Q27641100-2642879E-A0C3-469C-A068-C4BE9FA18378

Q27641100-3A2528F9-15DC-4D8C-8BF0-75E3A66E27C6

Q27641100-3C0F4C47-193A-492A-95C2-5CB2F700F8BB

Q27641100-40BE5ED6-4171-4E67-8744-6B2E88B3E384

P304

Q27641100-B77B0095-AFD6-4CD1-B567-A73781E77E7A

P31

Q27641100-BE2010A9-6937-4A0F-9B5D-AED552DB032D

P356

Q27641100-D7F1884A-BEDD-4970-A069-FA0704E58113

P407

Q27641100-4DB7843B-AF12-4BF1-8876-3E4731602385

P433

Q27641100-29189BEF-659F-484B-BA7B-C630E0A8E358

P478

Q27641100-07BAFF3F-6801-47D6-9334-A4DFF8E38597

P50

Q27641100-3B82E7FC-7146-4C91-9A76-9377B18BAF6C

P577

Q27641100-7B9DEE07-037C-4050-9C8B-72DA7B9F2ED0

P5875

Q27641100-55750B7C-B115-4629-B231-985620CA1A00

P698

Q27641100-23CF4EBD-2D60-40A1-A90B-06A57C72D9A2

P921

Q27641100-E9BD6817-E614-458C-ADD8-18278AE33FAB

P932

Q27641100-CAF00B5D-5994-4E61-B7F9-0D8F3557FF06

P356

J.BMC.2006.12.026

P1433

Bioorganic & Medicinal Chemistry

P1476

Crystal structure of the PXR–T ...... ential for receptor antagonism

@en

P2093

Esther Chao

http://www.w3.org/2001/XMLSchema#string

Jon L Collins

http://www.w3.org/2001/XMLSchema#string

Timothy M Willson

http://www.w3.org/2001/XMLSchema#string

William J Zuercher

http://www.w3.org/2001/XMLSchema#string

Yu Xue

http://www.w3.org/2001/XMLSchema#string

P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

P304

2156-66

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.BMC.2006.12.026

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

15

http://www.w3.org/2001/XMLSchema#string

P50

Matthew R Redinbo

P577

2007-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6586611

http://www.w3.org/2001/XMLSchema#string

P698

17215127

http://www.w3.org/2001/XMLSchema#string

P921

crystal structure

P932

1839856

http://www.w3.org/2001/XMLSchema#string