Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
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Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallographyKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationUpregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides.Cellular and molecular actions of Methylene Blue in the nervous systemThe discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies.Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse modelCerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease.Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-AmyloidInteraction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors?Non-synaptic roles of acetylcholinesterase and agrin.Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends.Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs.Dramatic increase in readthrough acetylcholinesterase in a cellular model of oxidative stress.Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's diseaseDesign, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.The neuroligins and their ligands: from structure to function at the synapse.Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy.Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer's Disease Through Activation of Canonical Wnt/β-Catenin Signalling Pathway.Neuroprotective Role of Novel Triazine Derivatives by Activating Wnt/β Catenin Signaling Pathway in Rodent Models of Alzheimer's Disease.Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis.Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains-A Structural Perspective.Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats.6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease.6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors.Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors.Therapy of Dredging the Bowels Enhanced the Neuroprotective Effect of Nourishing Kidney Herbs on Hippocampal Cholinergic System in Alzheimer's Disease Model Rat Induced by A 1-42
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P2860
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@en
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
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type
label
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@en
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@nl
prefLabel
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@en
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@nl
P2093
P2860
P1433
P1476
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.
@en
P2093
Alejandra Alvarez
Margarita C Dinamarca
Nibaldo C Inestrosa
P2860
P304
P356
10.1111/J.1742-4658.2007.06238.X
P407
P577
2008-01-17T00:00:00Z