A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops
about
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanismHigh-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformationsThe KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAKMCAK associates with the tips of polymerizing microtubulesThe KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegansA second tubulin binding site on the kinesin-13 motor head domain is important during mitosisExpression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agentsThe beginning of kinesin's force-generating cycle visualized at 9-A resolutionStructural model for strain-dependent microtubule activation of Mg-ADP release from kinesinStructure of the Kinesin13-Microtubule Ring ComplexATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome MovementInsight into the molecular mechanism of the multitasking kinesin-8 motorCrystal structure of the Kar3-like kinesin motor domain from the filamentous fungus Ashbya gossypiiPlus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle.The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear rolesIdentification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin.Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.A kinesin-13 mutant catalytically depolymerizes microtubules in ADPCatalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationLive visualizations of single isolated tubulin protein self-assembly via tunneling current: effect of electromagnetic pumping during spontaneous growth of microtubule.Kinesin-13 regulates the quantity and quality of tubulin inside cilia.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesThe death effector domains of caspase-8 induce terminal differentiation.A cool look at the structural changes in kinesin motor domainsPressure-induced changes in the structure and function of the kinesin-microtubule complex.Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interactionHow kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules.Flagellar kinesins in protists.Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.A molecular-mechanical model of the microtubuleMechanism of processive movement of monomeric and dimeric kinesin molecules.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAKA unique kinesin-8 surface loop provides specificity for chromosome alignmentThe contribution of αβ-tubulin curvature to microtubule dynamics.PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityNucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.
P2860
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P2860
A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A common mechanism for microtu ...... class-specific neck and loops
@ast
A common mechanism for microtu ...... class-specific neck and loops
@en
A common mechanism for microtu ...... class-specific neck and loops
@nl
type
label
A common mechanism for microtu ...... class-specific neck and loops
@ast
A common mechanism for microtu ...... class-specific neck and loops
@en
A common mechanism for microtu ...... class-specific neck and loops
@nl
prefLabel
A common mechanism for microtu ...... class-specific neck and loops
@ast
A common mechanism for microtu ...... class-specific neck and loops
@en
A common mechanism for microtu ...... class-specific neck and loops
@nl
P2093
P3181
P1433
P1476
A common mechanism for microtu ...... class-specific neck and loops
@en
P2093
Nobutaka Hirokawa
Tadayuki Ogawa
Yasushi Okada
P304
P3181
P356
10.1016/S0092-8674(04)00129-1
P407
P577
2004-02-20T00:00:00Z