Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

Item
http://www.wikidata.org/entity/Q27644443
Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assaysGenetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses.Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity.Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitorRecent Advances in Effect-directed Enzyme Assays based on Thin-layer Chromatography.Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition.Dipeptidyl peptidase-IV and related molecules: markers of malignancy?Novel DPP-4 inhibitors against diabetes.Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation.Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors.
P2860

Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

Item
http://www.wikidata.org/entity/Q27644443
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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name
Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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Rational design of a novel, po ...... crystallography of sitagliptin
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10.1016/J.BMCL.2007.03.095
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