Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡
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Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brainCrystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolutionStructural diversity of eukaryotic membrane cytochrome p450sCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyStructural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic ActivityStructures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side ChainsX-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocketHuman Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic MetabolismA Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational StatesStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylationCarboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase.Plasticity of CYP2B enzymes: structural and solution biophysical methods.Conformational plasticity and structure/function relationships in cytochromes P450.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and backInsights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR.
P2860
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P2860
Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@ast
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@en
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@nl
type
label
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@ast
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@en
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@nl
prefLabel
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@ast
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@en
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@nl
P2093
P2860
P356
P1433
P1476
Structural and Thermodynamic C ...... g to Cytochrome P450 2B4 † , ‡
@en
P2093
B K Muralidhara
C David Stout
James R Halpert
Mark A White
Santosh Kumar
Yonghong Zhao
P2860
P304
P356
10.1021/BI7011614
P407
P577
2007-10-16T00:00:00Z